(2E)-4-{[3-(ethoxycarbonyl)-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]amino}-4-oxobut-2-enoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: (2E)-4-{[3-(ethoxycarbonyl)-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]amino}-4-oxobut-2-enoic acid
• 英文别名: (E)-4-[[3-ethoxycarbonyl-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]amino]-4-oxobut-2-enoic acid
• 化学式: C₂₀H₂₇NO₅S
• 分子量: 393.5
• InChiKey: MQMHTCJUVXVTBQ-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• METHOD AND COMPOSITION FOR SKIN COLOR MODULATION
  申请人：Unilever PLC, A Company Registered in England and Wales under Company no. 41424

  公开号：EP2367522A2

  公开（公告）日：2011-09-28
• Method and Composition for Color Modulation
  申请人：Bajor John Steven

  公开号：US20100158829A1

  公开（公告）日：2010-06-24

  The invention is directed to a method and composition suitable for skin color modulation. Particularly, the action of D-dopachrome tautomerase on melanogenesis and/or the transfer of melanin from melanosomes in keratinocytes is reduced, thereby resulting in a change in skin color.
• [EN] METHOD AND COMPOSITION FOR COLOR MODULATION<br/>[FR] PROCÉDÉ ET COMPOSITION POUR MODULER LA COULEUR
  申请人：UNILEVER PLC

  公开号：WO2010072805A2

  公开（公告）日：2010-07-01

  The invention is directed to a method and composition suitable for skin color modulation. Particularly, the action of D-dopachrome tautomerase on melanogenesis and/or the transfer of melanin from melanosomes in keratinocytes is reduced, thereby resulting in a change in skin color.