N-benzyl-1-benzyl-2-methyl-6-oxopiperidine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-benzyl-1-benzyl-2-methyl-6-oxopiperidine-2-carboxamide
• 英文别名: N,1-dibenzyl-2-methyl-6-oxopiperidine-2-carboxamide
• 化学式: C₂₁H₂₄N₂O₂
• 分子量: 336.434
• InChiKey: SZLZAFUYNFQYFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-氧代己酸 在 甲醇 作用下， 以 甲醇 为溶剂， 反应 48.75h， 生成 N-benzyl-1-benzyl-2-methyl-6-oxopiperidine-2-carboxamide
  参考文献：
  名称：

  Synthesis of small and medium sized 2,2-disubstituted lactams via the “intramolecular” three component Ugi reaction

  摘要：

  A series of small and medium sized lactams were synthesized through the use of tethered keto-acids in an ''intramolecular'' multicomponent Ugi type reaction. This chemistry afforded five-, six-, seven- and eight-membered lactams in good yields. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)01265-3

文献信息

• Synthesis of five- and six-membered lactams via solvent-free microwave Ugi reaction
  作者：Mouhamad Jida、Sandra Malaquin、Rebecca Deprez-Poulain、Guillaume Laconde、Benoit Deprez

  DOI：10.1016/j.tetlet.2010.07.021

  日期：2010.9

  Five- and six-membered lactams were synthesized via a 4-center 3-component Ugi reaction by combining amines, isocyanides, and ketoacids under solvent-free microwave conditions. The reaction was carried out in much shorter times and the yields were improved in comparison to classical conditions.

  通过在无溶剂微波条件下将胺，异氰酸酯和酮酸合并，通过4中心3组分Ugi反应合成五元和六元内酰胺。与经典条件相比，该反应在短得多的时间内进行，并且产率得到提高。
• Synthesis of small and medium sized 2,2-disubstituted lactams via the “intramolecular” three component Ugi reaction
  作者：Geraldine C.B. Harriman

  DOI：10.1016/s0040-4039(97)01265-3

  日期：1997.8

  A series of small and medium sized lactams were synthesized through the use of tethered keto-acids in an ''intramolecular'' multicomponent Ugi type reaction. This chemistry afforded five-, six-, seven- and eight-membered lactams in good yields. (C) 1997 Elsevier Science Ltd.