2-Methyl-1-(1-phenylethyl)piperidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Methyl-1-(1-phenylethyl)piperidin-4-one
• 化学式: C₁₄H₁₉NO
• 分子量: 217.31
• InChiKey: XOGIRAQPVLKDBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS<br/>[FR] DERIVES TRICYCLIQUES ACCOLES POUR LE TRAITEMENT DE TROUBLES PSYCHOTIQUES
  申请人：GLAXO GROUP LTD

  公开号：WO2006024517A1

  公开（公告）日：2006-03-09

  Compounds of formula (I) wherein R1, R2, X, A, Y, B, Z1, Q, p, r and s are defined in the specification for treating inter alia psychotic disorders, depressive disorders, anxiety disorders and sexual dysfunctions.

  式中R1、R2、X、A、Y、B、Z1、Q、p、r和s在说明书中定义的用于治疗精神疾病、抑郁障碍、焦虑障碍和性功能障碍的(I)式化合物。
• [EN] (PIPERIDINYLOXY)PHENYL, (PIPERIDINYLOXY)PYRIDINYL, (PIPERIDINYLSULFANYL)PHENYL AND (PIPERIDINYLSULFANYL)PYRIDINYL COMPOUNDS AS 5-HT1F AGONISTS<br/>[FR] COMPOSES (PIPERIDINYLOXY)PHENYLE, (PIPERIDINYLOXY)PYRIDINYLE, (PIPERIDINYLSULFANYL)PHENYLE ET (PIPERIDINYLSULFANYL)PYRIDINYLE UTILISES COMME AGONISTES DES RECEPTEURS 5-HT1F
  申请人：LILLY CO ELI

  公开号：WO2004094380A1

  公开（公告）日：2004-11-04

  The present invention relates to compounds of formula 1: and pharmaceutically acceptable acid addition sails thereof. The compounds of the present invention are useful for activating 5-HTIF receptors, inhibiting neuronal protein extravasation, and for the treatment or preverition of migraine in mammals, particularly humans.

  本发明涉及公式1的化合物及其药用可接受的酸盐。本发明的化合物可用于激活5-HTIF受体，抑制神经蛋白外渗，并用于治疗或预防哺乳动物，尤其是人类的偏头痛。
• (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-ht1f agonists
  申请人：Blanco-Pillado Maria-Jesus

  公开号：US20060211734A1

  公开（公告）日：2006-09-21

  The present invention relates to compounds of formula 1: and pharmaceutically acceptable acid addition sails thereof. The compounds of the present invention are useful for activating 5-HT 1F receptors, inhibiting neuronal protein extravasation, and for the treatment or preverition of migraine in mammals, particularly humans.

  本发明涉及公式1的化合物及其药学上可接受的酸盐。本发明的化合物对于激活5-HT1F受体、抑制神经蛋白外渗以及治疗或预防哺乳动物，特别是人类的偏头痛具有用途。
• (PIPERIDINYLOXY)PHENYL, (PIPERIDINYLOXY)PYRIDINYL, (PIPERIDINYLSULFANYL)PHENYL AND (PIPERIDINYLSULFANYL)PYRIDINYL COMPOUNDS AS 5-HT 1F AGONISTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1626958B1

  公开（公告）日：2012-06-27
• FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1786822A1

  公开（公告）日：2007-05-23