3,5-Bis(4-fluorobenzylidene)-4-piperidinone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3,5-Bis(4-fluorobenzylidene)-4-piperidinone
• 英文别名: (3Z,5Z)-3,5-bis[(4-fluorophenyl)methylidene]piperidin-4-one
• 化学式: C₁₉H₁₅F₂NO
• 分子量: 311.3
• InChiKey: ASJBYMPCFLKDGD-VULZFCBJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Spirooxindole-pyrrolothiazole heterocyclic hybrids
  申请人：KING SAUD UNIVERSITY

  公开号：US10590147B1

  公开（公告）日：2020-03-17

  The spirooxindole-pyrrolothiazole heterocyclic hybrids are compounds having the formula: wherein R is hydrogen and R′ is fluorine (compound 6a) or R is fluorine and R′ is hydrogen (compound 6b). The hybrids may be obtained using a chemical synthesis process involving 1,3-dipolar cycloaddition of 3,5-bis(4/2-fluoro-benzylidene) piperidin-4-ones with isatin and 4-thiazolidinecarboxylic acid in a suitable solvent, preferably 1-butyl-3-methyl-imidazolium bromide (“[bmim]Br”), and preferably under microwave irradiation. Both of these new hybrids demonstrate antimicrobial activity against both gram positive and gram negative drug resistant and non-resistant bacterial pathogens, although compound 6a exhibits more potent antibacterial activity than compound 6b.

  螺环氧吲哚-吡咯噻唑杂环混合物是具有以下化学式的化合物：其中R为氢，R′为氟（化合物6a），或者R为氟，R′为氢（化合物6b）。这些杂合物可以通过化学合成过程获得，涉及3,5-双(4/2-氟苄亚甲基)哌啶-4-酮与吲哚酮和4-噻唑烷羧酸进行1,3-偶极环加成，在适当溶剂中，最好是1-丁基-3-甲基-咪唑溴化物（“[bmim]Br”），并最好在微波辐射下进行。这两种新的杂合物对革兰氏阳性和革兰氏阴性耐药和非耐药细菌病原体均表现出抗菌活性，尽管化合物6a表现出比化合物6b更强的抗菌活性。
• [EN] COMPOSITIONS AND METHODS FOR INHIBITION OF CANCERS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR L'INHIBITION DE CANCERS
  申请人：UNIV OHIO STATE RES FOUND

  公开号：WO2011005790A1

  公开（公告）日：2011-01-13

  Methods and compositions for treating cancers, including ovarian cancers, are described. The compositions generally include a redox based curcumin derivative, diarylidenylpiperiden-4-one (DAP) having a hydroxylamine moiety attached thereto.

  描述了用于治疗癌症的方法和组合物，包括卵巢癌。这些组合物通常包括一种基于氧化还原的姜黄素衍生物，即联苯亚基哌啶-4-酮（DAP），其上附有一个羟胺基团。
• ANTIPROLIFERATIVE COMPOSITIONS COMPRISING CURCUMIN ANALOGS AND METHODS OF PRODUCING AND USING SAME
  申请人：Awasthi Vibhudutta

  公开号：US20120288555A1

  公开（公告）日：2012-11-15

  Antiproliferative compositions that include CLEFMA, as well as liposomal compositions containing said antiproliferative compositions, are disclosed. Also disclosed are methods of making and using the antiproliferative compositions and liposomal compositions.

  本文披露了包含CLEFMA的抗增殖组合物，以及含有该抗增殖组合物的脂质体组合物。还披露了制备和使用抗增殖组合物和脂质体组合物的方法。
• COMPOSITIONS AND METHODS FOR INHIBITION OF CANCERS
  申请人：The Ohio State University Research Foundation

  公开号：EP2451273A1

  公开（公告）日：2012-05-16
• Compositions and Methods for Inhibition of Cancers
  申请人：Kuppusamy Periannan

  公开号：US20120316203A1

  公开（公告）日：2012-12-13

  Methods and compositions for treating cancers, including ovarian cancers, are described. The compositions generally include a redox based curcumin derivative, diarylidenylpiperiden-4-one (DAP) having a hydroxylamine moiety attached thereto.