N'-(4-methylbenzylidene)-2-thiophenecarbohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: N'-(4-methylbenzylidene)-2-thiophenecarbohydrazide
• 英文别名: N-[(E)-(4-methylphenyl)methylideneamino]thiophene-2-carboxamide
• 化学式: C₁₃H₁₂N₂OS
• 分子量: 244.31
• InChiKey: GPBDMHOZKSIYPB-NTEUORMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• METHODS OF FACILITATING NEURAL CELL SURVIVAL USING GDNF FAMILY LIGAND (GFL) MIMETICS OR RET SIGNALING PATHWAY ACTIVATORS
  申请人：Genecode AS

  公开号：EP2509953B1

  公开（公告）日：2016-03-30
• Methods of Facilitating Neural Cell Survival Using GDNF Family Ligand (GFL) Mimetics or RET Signaling Pathway Activators
  申请人：Saarma Mart

  公开号：US20130030180A1

  公开（公告）日：2013-01-31

  Disclosed are compounds and methods for treating neurological and other disorders by administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for GFRα receptor molecules, which can be mimetics of glial-derived neurotrophic factor (GDNF) family ligands (GFLs), GFRα/RET signaling pathway agonists, and/or direct RET agonists (activators).
• Method for Treating Peripheral Neuropathy
  申请人：CHEMEDEST LTD.

  公开号：US20160136159A1

  公开（公告）日：2016-05-19

  A method of treating or preventing peripheral neuropathy in a subject determined to be in need thereof comprising: topically administering to the subject an anti-peripheral neuropathic compound acting as GFRα3 type receptor agonist.
• Method of treating peripheral neuropathy
  申请人：Chemedest Ltd.

  公开号：US20180036305A1

  公开（公告）日：2018-02-08

  Compositions and methods for treating or preventing peripheral neuropathy in a subject determined to be in need thereof. The method comprises a step of topically administering to the subject anti-peripheral neuropathic compounds acting as GFRα3 type receptor agonist.
• US8901129B2
  申请人：——

  公开号：US8901129B2

  公开（公告）日：2014-12-02