4-methyl-2-(2,2,3,3-tetrafluoropropoxy)-1,3,2-dioxaphospholane

• 分子结构分类: 有机化合物 - 有机磷化合物 - 亚磷酸三烷基酯
• 英文名称: 4-methyl-2-(2,2,3,3-tetrafluoropropoxy)-1,3,2-dioxaphospholane
• 英文别名: 4-Methyl-2-(2,2,3,3-tetrafluoropropoxy)-1,3,2-di-oxaphospholane
• 化学式: C₆H₉F₄O₃P
• 分子量: 236.103
• InChiKey: SDNMWYQPIBWLGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-氯-4-甲基-1,3,2-二氧杂磷杂环戊烷 、 四氟丙醇 在 三乙胺 作用下， 以 正己烷 为溶剂， 以20%的产率得到
  参考文献：
  名称：

  Synthesis and Isomer Composition of 2-Polyfluoroalkoxy-1,3,2-dioxaphospholanes and -phosphinanes

  摘要：

  Polyfluoroalkanols readily reacted with 2-chloro-1,3,2-dioxaphospholanes and 2-chloro-1,3,2-dioxaphosphinanes in hexane in the presence of triethylamine (-10 to 25A degrees C, 5 h) to give 2-polyfluoroalkoxy-1,3,2- dioxaphospholanes and 2-polyfluoroalkoxy-1,3,2-dioxaphosphinanes in 48-72% yield. The products were found to exist as mixtures of cis and trans isomers with the trans isomer predominating for the phospholanes and cis isomer predominating for the phosphinanes according to the H-1, C-13, F-19, and P-31 NMR data.

  DOI：

  10.1134/s107036321804014x

文献信息

• Synthesis and Isomer Composition of 2-Polyfluoroalkoxy-1,3,2-dioxaphospholanes and -phosphinanes
  作者：N. K. Gusarova、S. I. Verkhoturova、S. N. Arbuzova、T. I. Kazantseva、A. I. Albanov、A. M. Nalibaeva、G. K. Bishimbaeva、K. A. Apartsin、V. V. Kireeva、B. A. Trofimov

  DOI：10.1134/s107036321804014x

  日期：2018.4

  Polyfluoroalkanols readily reacted with 2-chloro-1,3,2-dioxaphospholanes and 2-chloro-1,3,2-dioxaphosphinanes in hexane in the presence of triethylamine (-10 to 25A degrees C, 5 h) to give 2-polyfluoroalkoxy-1,3,2- dioxaphospholanes and 2-polyfluoroalkoxy-1,3,2-dioxaphosphinanes in 48-72% yield. The products were found to exist as mixtures of cis and trans isomers with the trans isomer predominating for the phospholanes and cis isomer predominating for the phosphinanes according to the H-1, C-13, F-19, and P-31 NMR data.