3-[(aminocarbonyl)amino]-5-{3-[2-(dimethylamino)ethoxy]phenyl}-2-thiophenecarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 3-[(aminocarbonyl)amino]-5-{3-[2-(dimethylamino)ethoxy]phenyl}-2-thiophenecarboxamide
• 英文别名: 3-(carbamoylamino)-5-[3-[2-(dimethylamino)ethoxy]phenyl]thiophene-2-carboxamide
• 化学式: C₁₆H₂₀N₄O₃S
• 分子量: 348.426
• InChiKey: XMWDYFPXVMZZQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  139
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯-N,N-二甲基乙胺 、 3-[(aminocarbonyl)amino]-5-(3-hydroxyphenyl)-2-thiophenecarboxamide 生成 3-[(aminocarbonyl)amino]-5-{3-[2-(dimethylamino)ethoxy]phenyl}-2-thiophenecarboxamide
  参考文献：
  名称：

  Novel Compounds

  摘要：

  该发明涉及式(I)的杂芳香族羧酰胺，其中A，R1，R2和X在说明书中定义，用于制备它们的过程和中间体，包含它们的制药组合物以及它们在治疗中的使用。

  公开号：

  US20020107252A1

文献信息

• Novel Compounds
  申请人：——

  公开号：US20020107252A1

  公开（公告）日：2002-08-08

  The invention relates to heteroaromatic carboxamides of formula (I), 1 wherein A, R 1 , R 2 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  这项发明涉及到式(I)的杂环芳香族羧酰胺， 其中A、R1、R2和X如规范中定义，以及用于它们制备的过程和中间体，含有它们的药物组合物以及它们在治疗中的应用。
• [EN] HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2<br/>[FR] DERIVES DE CARBOXAMIDES HETEROAROMATIQUES ET LEUR UTILISATION COMME INHIBITEURS DE L'ENZYME IKK-2
  申请人：ASTRAZENECA AB

  公开号：WO2001058890A1

  公开（公告）日：2001-08-16

  The invention relates to heteroaromatic carboxamides of formula (I), wherein A, R1, R2 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及式（I）的杂环芳香族羧酰胺，其中A，R1，R2和X如规范中定义的过程和中间体，制备它们所用的制剂，含有它们的制药组合物以及它们在治疗中的使用。
• Substituted Thiophene compounds
  申请人：AstraZeneca AB

  公开号：US07358376B2

  公开（公告）日：2008-04-15

  The invention relates to heteroaromatic carboxamides of formula (I), wherein A, R1, R2 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及公式（I）的杂环芳香族羧酰胺，其中A，R1，R2和X如规范中所定义，以及用于其制备的过程和中间体，包含它们的制药组合物以及它们在治疗中的使用。
• HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2
  申请人：AstraZeneca AB

  公开号：EP1261600A1

  公开（公告）日：2002-12-04
• Compositions of a cyclooxygenase-2 selective inhibitor and an IKK inhibitor for the treatment of ischemic mediated central nervous system disorders or injury
  申请人：Stephenson T. Diane

  公开号：US20050075341A1

  公开（公告）日：2005-04-07

  The present invention provides compositions and methods for the treatment of ischemic-mediated central nervous system disorders or injuries. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic-mediated disorder or injury comprising the administration to a subject of a cyclooxygenase-2 selective inhibitor and an IKK inhibitor.