thiophene-2-carboxylic acid bis(2-methoxyethyl)amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: thiophene-2-carboxylic acid bis(2-methoxyethyl)amide
• 英文别名: N,N-bis(2-methoxyethyl)thiophene-2-carboxamide
• 化学式: C₁₁H₁₇NO₃S
• mdl: MFCD21366321
• 分子量: 243.327
• InChiKey: QWHSQTZNMNURKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.545
• 拓扑面积：
  67
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-噻吩甲酸 、 [双(2-甲氧基乙基)胺]三氟化硫 在 N,N-二异丙基乙胺 、 二异丙胺 作用下， 以 二氯甲烷 为溶剂， 反应 22.0h， 以89%的产率得到thiophene-2-carboxylic acid bis(2-methoxyethyl)amide
  参考文献：
  名称：

  [Bis(2-methoxyethyl)amino]sulfur Trifluoride, the Deoxo-Fluor Reagent:  Application toward One-Flask Transformations of Carboxylic Acids to Amides

  摘要：

  The use of the Deoxo-Fluor reagent is a versatile method for acyl fluoride generation and subsequent one-flask amide coupling. It provides mild conditions and facile purification of the desired products in good to excellent yields. We have explored the utility of this reagent for the one-flask conversion of acids to amides and Weinreb amides and as a peptide-coupling reagent.

  DOI：

  10.1021/jo035658k

文献信息

• [Bis(2-methoxyethyl)amino]sulfur Trifluoride, the Deoxo-Fluor Reagent:  Application toward One-Flask Transformations of Carboxylic Acids to Amides
  作者：Jonathan M. White、Ashok Rao Tunoori、Brandon J. Turunen、Gunda I. Georg

  DOI：10.1021/jo035658k

  日期：2004.4.1

  The use of the Deoxo-Fluor reagent is a versatile method for acyl fluoride generation and subsequent one-flask amide coupling. It provides mild conditions and facile purification of the desired products in good to excellent yields. We have explored the utility of this reagent for the one-flask conversion of acids to amides and Weinreb amides and as a peptide-coupling reagent.