外-3-甲基-6-氨基-3-氮杂双环[3.1.0]己烷 | 164799-15-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 外-3-甲基-6-氨基-3-氮杂双环[3.1.0]己烷
• 英文名称: Exo-3-methyl-6-amino-3-azabicyclo[3.1.0]hexane
• 英文别名: (1S,5R)-3-methyl-3-azabicyclo[3.1.0]hexan-6-amine
• CAS: 164799-15-9
• 化学式: C₆H₁₂N₂
• 分子量: 112.17
• InChiKey: YSRSYYHGSQMAFV-XEAPYIEGSA-N

物化性质

• 沸点：
  140.6±8.0 °C(Predicted)
• 密度：
  1.057±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF
  申请人：CHOY Allison Laura

  公开号：US20100317624A1

  公开（公告）日：2010-12-16

  Compounds of formula (IA) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

  公式（IA）的化合物及其药用可接受的盐被描述。还描述了它们的制备过程、含有它们的药物组合物、它们作为药物的使用以及它们在治疗细菌感染中的用途。
• PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT
  申请人：Gilead Sciences, Inc.

  公开号：US20140154240A1

  公开（公告）日：2014-06-05

  The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

  本发明提供了I式或II式的化合物： 或其药学上可接受的盐或酯，如本文所述。这些化合物及其组合物对治疗Pneumovirinae病毒感染有用。所提供的化合物、组合物和方法特别适用于治疗人类呼吸道合胞病毒感染。
• HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

  公开号：EP3889152A1

  公开（公告）日：2021-10-06

  The present invention relates to heteroaromatic derivatives for use as a regulator, a preparation method therefor and a use thereof. In particular, disclosed are compounds represented by general formula (I), preparation methods therefor, pharmaceutical compositions comprising said compounds, and a use thereof as Janus kinase inhibitors in treating inflammatory diseases and tumor-related diseases.

  本发明涉及用作调节剂的杂芳香族衍生物、其制备方法及其用途。特别是，本发明公开了通式（I）代表的化合物、其制备方法、包含所述化合物的药物组合物，以及其作为 Janus 激酶抑制剂在治疗炎症性疾病和肿瘤相关疾病中的用途。
• PYRIMIDINE-BASED COMPOUNDS FOR THE TREATMENT OF CANCER
  申请人：G1 Therapeutics, Inc.

  公开号：US20190119294A1

  公开（公告）日：2019-04-25

  This invention is in the area of pyrimidine-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.
• PYRIMIDINE-BASED ANTIPROLIFERATIVE AGENTS
  申请人：G1 Therapeutics, Inc.

  公开号：US20210047328A1

  公开（公告）日：2021-02-18

  This invention is in the area of pyrimidine-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.