DMTr-amide-L-proline

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: DMTr-amide-L-proline
• 英文别名: N-(4-O-DMTr-hydroxybutyl)-L-prolinamide；(2S)-N-[4-[bis(4-methoxyphenyl)-phenylmethoxy]butyl]pyrrolidine-2-carboxamide
• 化学式: C₃₀H₃₆N₂O₄
• 分子量: 488.627
• InChiKey: LMBYCQVNRBEMFW-NDEPHWFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  68.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  DMTr-amide-L-proline 在 二异丙基铵盐四氮唑 、 1-羟基苯并三唑 、 1,2-二氯乙烷 、 三乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 3.0h， 生成 DMTr-diamide-L-proline amidite
  参考文献：
  名称：

  Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton

  摘要：

  提供的是一种新型核酸分子，可以轻松高效地制备，并且可以抑制基因的表达。该核酸分子是一种包括抑制表达目标基因的表达抑制序列的单链核酸分子。该单链核酸分子包括：一个区域（X）；一个连接区域（Lx）；和一个区域（Xc）。连接区域（Lx）连接在区域（Xc）和（Xc）之间。区域（Xc）与区域（X）互补。区域（X）和（Xc）中至少一个包括表达抑制序列。连接区域（Lx）具有非核苷酸结构，包括至少一个吡咯烷骨架和一个哌啶骨架。根据这种单链核酸分子，可以抑制目标基因的表达。

  公开号：

  US09200278B2
• 作为产物：
  描述：

  在 哌啶 作用下， 以 甲苯 为溶剂， 反应 0.5h， 生成 DMTr-amide-L-proline
  参考文献：
  名称：

  METHOD FOR PRODUCING MONOMER FOR SINGLE-STRANDED NUCLEIC ACID MOLECULE

  摘要：

  通过在溶剂中添加1-羟基苯并三唑和缩合剂的存在，将由式（1）表示的化合物或其对映体与6-羟基己酸反应，然后混合产生的反应混合物、水和碱金属氢氧化物，可以获得由式（2）表示的化合物或其对映体；并且将由式（2）表示的化合物或其对映体与2-氰乙基-N，N，N'，N' -四异丙基膦酰胺在溶剂中反应，在偶联活化剂的存在下。

  公开号：

  US20190100540A1

文献信息

• Single-stranded nucleic acid molecule for regulating expression of gene having delivering function
  申请人：Bonac Corporation

  公开号：US09663784B2

  公开（公告）日：2017-05-30

  The invention provides a single-stranded nucleic acid capable of inhibiting expression of a target gene having a delivery function. The nucleic acid contains, from the 5′-side to the 3′-side, a 5′-side region (Xc), a linker region (Lx), an inner region (Z), a linker region (Ly) and a 3′-side region (Yc) in this order, wherein the inner region (Z) is constituted by linkage of the inner 5′-side region (X) and the inner 3′-side region (Y), the 5′-side region (Xc) is complementary to the inner 5′-side region (X), the 3′-side region (Yc) is complementary to the inner 3′-side region (Y), at least one of the inner region (Z), the 5′-side region (Xc) and the 3′-side region (Yc) comprises an expression inhibitory sequence that inhibits expression of a target gene, and at least one of the 5′-terminus, the 3′-terminus, the linker region (Lx) and the linker region (Ly) is bound to a bio-related substance.

  该发明提供了一种能够抑制具有传递功能的靶基因表达的单链核酸。该核酸从5'-端到3'-端依次包含一个5'-端区域（Xc）、一个连接区域（Lx）、一个内部区域（Z）、一个连接区域（Ly）和一个3'-端区域（Yc），其中内部区域（Z）由内部5'-端区域（X）和内部3'-端区域（Y）连接而成，5'-端区域（Xc）与内部5'-端区域（X）互补，3'-端区域（Yc）与内部3'-端区域（Y）互补，至少其中之一的内部区域（Z）、5'-端区域（Xc）和3'-端区域（Yc）包含可抑制靶基因表达的表达抑制序列，且至少其中之一的5'-端、3'-端、连接区域（Lx）和连接区域（Ly）与生物相关物质结合。
• SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR CONTROLLING GENE EXPRESSION
  申请人：Ohgi Tadaaki

  公开号：US20120010271A1

  公开（公告）日：2012-01-12

  Provided is a novel nucleic acid molecule that can inhibit the expression of a gene and can be produces easily and efficiently. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes, in sequence from the 5′ side to the 3′ side: a 5′ side region (Xc); an inner region (Z); and a 3′ side region (Yc). The inner region (Z) is composed of an inner 5′ side region (X) and an inner 3′ side region (Y) that are linked to each other. The 5′ side region (Xc) is complementary to the inner 5′ side region (X). The 3′ side region (Yc) is complementary to the inner 3′ side region (Y). At least one of the inner region (Z), the 5′ side region (Xc), and the 3′ side region (Yc) includes the expression inhibitory sequence. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

  提供了一种新型的核酸分子，可以抑制基因表达，并且可以轻松高效地制备。该核酸分子是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。从5'端到3'端，该单链核酸分子包括：5'端区域（Xc），内部区域（Z）和3'端区域（Yc）。内部区域（Z）由内部5'端区域（X）和内部3'端区域（Y）组成，二者相连。5'端区域（Xc）与内部5'端区域（X）互补。3'端区域（Yc）与内部3'端区域（Y）互补。至少其中之一包括表达抑制序列。通过这种单链核酸分子，可以抑制目标基因的表达。
• SINGLE-STRANDED NUCLEIC ACID MOLECULE HAVING NITROGEN-CONTAINING ALICYCLIC SKELETON
  申请人：Ohgi Tadaaki

  公开号：US20120035246A1

  公开（公告）日：2012-02-09

  Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes: a region (X); a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At least one of the regions (X) and (Xc) includes the expression inhibitory sequence. The linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

  提供了一种新型的核酸分子，可以轻松高效地制备，并能抑制基因表达。该核酸分子是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。该单链核酸分子包括：一个区域（X）；一个连接区域（Lx）；和一个区域（Xc）。连接区域（Lx）连接在区域（Xc）和（Xc）之间。区域（Xc）与区域（X）互补。至少其中一个区域（X）和（Xc）包含表达抑制序列。连接区域（Lx）具有非核苷酸结构，包括至少一个吡咯烷骨架和一个哌啶骨架。根据这种单链核酸分子，可以抑制目标基因的表达。
• Single-Stranded Nucleic Acid Molecule Having Nitrogen-Containing Alicyclic Skeleton
  申请人：BONAC CORPORATION

  公开号：US20140171633A1

  公开（公告）日：2014-06-19

  Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes: a region (X); a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At least one of the regions (X) and (Xc) includes the expression inhibitory sequence. The linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

  提供一种新型核酸分子，可以轻松高效地制备，并且可以抑制基因表达。该核酸分子是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。该单链核酸分子包括：区域（X）；连接区域（Lx）；和区域（Xc）。连接区域（Lx）连接在区域（Xc）和（Xc）之间。区域（Xc）与区域（X）互补。区域（X）和（Xc）中至少有一个包含表达抑制序列。连接区域（Lx）具有非核苷酸结构，包括至少一个吡咯烷骨架和哌啶骨架。根据这种单链核酸分子，可以抑制目标基因的表达。
• Single-Stranded Nucleic Acid Molecule for Controlling Gene Expression
  申请人：BONAC CORPORATION

  公开号：US20150011605A1

  公开（公告）日：2015-01-08

  Provided is a novel nucleic acid molecule that is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes, in sequence from the 5′ side to the 3′ side: a 5′ side region (Xc); an inner region (Z); and a 3′ side region (Yc). The inner region (Z) is composed of an inner 5′ side region (X) and an inner 3′ side region (Y) that are linked to each other. The 5′ side region (Xc) is complementary to the inner 5′ side region (X). The 3′ side region (Yc) is complementary to the inner 3′ side region (Y). At least one of the inner region (Z), the 5′ side region (Xc), and the 3′ side region (Yc) includes the expression inhibitory sequence.

  提供的是一种新型核酸分子，它是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。该单链核酸分子从5'端到3'端的序列包括：一个5'端区域（Xc）；一个内部区域（Z）；以及一个3'端区域（Yc）。内部区域（Z）由内部5'端区域（X）和内部3'端区域（Y）组成，它们彼此连接。5'端区域（Xc）与内部5'端区域（X）互补。3'端区域（Yc）与内部3'端区域（Y）互补。内部区域（Z）、5'端区域（Xc）和3'端区域（Yc）中至少有一个包含表达抑制序列。