(1S)-1,5-脱水-1-[5,7,8-三羟基-2-(4-羟基苯基)-4-羰基-4H-色烯-6-基]-D-半乳糖醇 | 73207-93-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: (1S)-1,5-脱水-1-[5,7,8-三羟基-2-(4-羟基苯基)-4-羰基-4H-色烯-6-基]-D-半乳糖醇
• 中文别名: (1,1-二甲基哌啶-1-鎓-3-基)甲醇
• 英文名称: 3-Hydroxymethyl-N,N-dimethylpiperidinium
• 英文别名: (1,1-dimethylpiperidin-1-ium-3-yl)methanol
• CAS: 73207-93-9
• 化学式: C8H18NO+
• 分子量: 144.23
• InChiKey: HYWXCEOOYVGLSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Novel benzothiazepine and bensothiepine compounds
  申请人：Sasahara Takehiko

  公开号：US20070190041A1

  公开（公告）日：2007-08-16

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substitutent:

  提供了一种药物，可用作治疗和预防高脂血症的治疗剂和预防剂，以及一种药物，可用作治疗和预防与胆汁淤积有关的肝脏疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的治疗剂和预防剂，以及一种药物，可用作治疗和预防肥胖症、脂肪肝和脂肪性肝炎的治疗剂和预防剂。化合物的苯并噻吩或苯并噻环代表如下式（1A），具有硫酰胺键和季铵取代基：
• Novel quaternary ammonium compounds
  申请人：Sasahara Takehiko

  公开号：US20070203115A1

  公开（公告）日：2007-08-30

  A method for inhibiting ileal bile acid transporter activity in a subject, comprising administering to said subject an effective amount of a compound represented by formula (1):

  一种抑制回肠胆汁酸转运蛋白活性的方法，包括向该受试者施用一种由式（1）所代表的化合物的有效量：
• NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS
  申请人：SASAHARA Takehiko

  公开号：US20120015925A1

  公开（公告）日：2012-01-19

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substituent:

  提供了一种作为治疗剂和预防剂用于高脂血症的药物，以及一种作为治疗剂和预防剂用于与胆汁淤积相关的肝疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的药物，以及一种作为治疗剂和预防剂用于肥胖症、脂肪肝和脂肪性肝炎的药物。该药物是一种具有硫酰胺键和季铵基取代基的苯并噻吩或苯并噻吩化合物，其化学式为（1A）。
• Novel glycerol derivative and anti-hypertensive agent
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：EP0284395A2

  公开（公告）日：1988-09-28

  A novel glycerol derivative which is effective to reduce blood pressure has the formula: wherein R¹ is an alkyl group having 10-22 carbon atoms, R² is lower acyl, benzoyl, aryl, mono-, di- or triaryl­alkyl, alkyl, cycloalkyl, or cycloalkylalkyl; Q is sub­stituted or unsubstituted alkylene containing 1-4 carbon atoms, ℓ is 0 or 1; Y is a nitrogen-containing heterocy­clic group or a nitrogen-containing bridged heterocyclic group (-(Q)ℓ- is attached to a carbon atom contained in a hetero-ring of the heterocyclic group) in which Y is the bridged heterocyclic group where ℓ is 0; and each of R⁵, R⁶ and R⁷ is hydrogen, lower alkyl, aryl or aralkyl.

  一种有效降低血压的新型甘油衍生物具有以下式子： 其中R¹是具有10-22个碳原子的烷基，R²是低级酰基、苯甲酰基、芳基、单芳烷基、二芳烷基或三芳烷基、烷基、环烷基或环烷基烷基；Q是含有1-4个碳原子的取代或未取代的亚烷基，ℓ是0或1；Y 是含氮杂环基团或含氮桥接杂环基团（-(Q)ℓ- 连接到杂环基团的杂环中所含的碳原子上），其中 Y 是桥接杂环基团，其中 ℓ 为 0；以及 R⁵、R⁶ 和 R⁷ 中的每一个都是氢、低级烷基、芳基或芳烷基。
• METHOD OF TREATING AND DIAGNOSING SLEEP DISORDERED BREATHING AND MEANS FOR CARRYING OUT THE METHOD
  申请人：A+ Science Invest AB

  公开号：EP0923370A2

  公开（公告）日：1999-06-23