(2-碘-N-甲基-N-[2-[甲基(7-硝基-2,1,3-苯并恶二唑-4-基)氨基]乙基]-乙酰胺) | 173485-12-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶二唑类
• 中文名称: (2-碘-N-甲基-N-[2-[甲基(7-硝基-2,1,3-苯并恶二唑-4-基)氨基]乙基]-乙酰胺)
• 中文别名: 2-碘-n-甲基-n-(2-(甲基(7-硝基苯并[c][1,2,5]噁二唑-4-基)氨基)乙基)乙酰胺
• 英文名称: 2-Iodo-N-methyl-N-(2-(methyl(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)ethyl)acetamide
• 英文别名: 2-iodo-N-methyl-N-[2-[methyl-(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]ethyl]acetamide
• CAS: 173485-12-6
• 化学式: C12H14IN5O4
• 分子量: 419.18
• InChiKey: NIYRYQYZEATYFF-UHFFFAOYSA-N

物化性质

• 沸点：
  553.9±60.0 °C(Predicted)
• 密度：
  1.807±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  7

安全信息

• 海关编码：
  2934999090

文献信息

• FLUOROGENIC PROTEIN KINASE SUBSTRATES
  申请人：Gee Kyle

  公开号：US20080009026A1

  公开（公告）日：2008-01-10

  The present invention relates to kinase sensors comprising a metal chelator and a fluorophore, where the chelator comprises a quinoline group and where the fluorophore is conjugated to the chelator. The invention also relates to methods of using these kinase sensors as well as kits comprising the kinase sensors.

  本发明涉及一种激酶传感器，包括金属螯合剂和荧光染料，其中螯合剂包括喹啉基团，荧光染料与螯合剂结合。本发明还涉及使用这些激酶传感器的方法以及包含这些激酶传感器的试剂盒。
• Multimers of MHC-peptide complexes and uses thereof in Borrelia infectious diseases
  申请人：Dako Denmark A/S

  公开号：EP2361930A2

  公开（公告）日：2011-08-31

  The present application concerns multimers of MHC-peptide complexes, in particular, dextramers, wherein the peptide is a 9-mer derived from a Borrelia outer surface protein antigen. The application is also directed to compositions, kits and vaccines comprising said MHC multimers and uses thereof in immuno-monitoring, diagnosis, and therapy, especially to detect specific T cells.

  本申请涉及 MHC-肽复合物的多聚体，特别是右旋聚体，其中的肽是源自包柔氏外表面蛋白抗原的 9 聚体。本申请还涉及包含上述 MHC 多聚体的组合物、试剂盒和疫苗，以及它们在免疫监测、诊断和治疗中的用途，特别是用于检测特异性 T 细胞。
• Biomolecule complexes as contrast agents in Positron Emission Tomography (PET) based methods for the assessment of organ function
  申请人：Bergen Teknologioverforing AS

  公开号：EP2428231A2

  公开（公告）日：2012-03-14

  The present invention relates to complexes comprising one or more markers and one or more biomolecules for use as a contrast agent in positron emission tomography based imaging. The complexes according to the present invention preferably accumulate in a target compartment, such as the kidney. The present invention further relates to methods for generating the complexes and methods for using the complexes such as for evaluation of different aspects of kidney functionality e.g. for calculation of total and/or regional glomerular filtration rate in the kidney without the need for sampling blood or urine.

  本发明涉及由一种或多种标记物和一种或多种生物分子组成的复合物，可用作基于正电子发射断层扫描成像的造影剂。根据本发明的复合物优选在靶区，如肾脏中蓄积。本发明进一步涉及生成复合物的方法和使用复合物的方法，例如用于评估肾脏功能的不同方面，如计算肾脏的总和/或区域肾小球滤过率，而无需抽取血液或尿液样本。
• IMPROVED METHODS FOR GENERATION, LABELING AND USE OF MHC MULTIMERS
  申请人：Dako Denmark A/S

  公开号：EP3023436A1

  公开（公告）日：2016-05-25

  The present invention describes novel methods to generate MHC multimers and methods to improve existing and new MHC multimers. The invention also describes improved methods for the use of MHC multimers in analysis of T-cells in samples including diagnostic and prognostic methods. Furthermore the use of MHC multimers in therapy are described, e.g. anti-tumour and anti-virus therapy, including isolation of antigen specific T-cells capable of inactivation or elimination of undesirable targeT-cells or isolation of specific T-cells capable of regulation of other immune cells.

  本发明描述了生成 MHC 多聚物的新方法以及改进现有和新 MHC 多聚物的方法。本发明还描述了在分析样本中的 T 细胞时使用 MHC 多聚物的改进方法，包括诊断和预后方法。此外，本发明还描述了 MHC 多聚体在治疗中的应用，例如抗肿瘤和抗病毒治疗，包括分离抗原特异性 T 细胞，使其能够灭活或消除不需要的 T 细胞，或分离能够调节其他免疫细胞的特异性 T 细胞。
• COMPOSITIONS COMPRISING A PH-SENSITIVE MEMBRANE INSERTION POLIPEPTIDE
  申请人：University of Rhode Island Board of Trustees

  公开号：EP4098272A2

  公开（公告）日：2022-12-07

  An environmentally sensitive membrane binding polypeptide, pH (low) -sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.

  一种对环境敏感的膜结合多肽--pH 值（低）敏感膜肽（pHLIP）具有更好的插入动力学和可溶性，可选择性地靶向酸性组织。