(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;formic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;formic acid
• 化学式: C20H22FNO5
• 分子量: 375.4
• InChiKey: AYYSAGIIHFXWQY-RVXRQPKJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.03
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  77
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Optimized procedures for the manufacture of paroxetine salts
  申请人：——

  公开号：US20030032809A1

  公开（公告）日：2003-02-13

  Described herein are methods for manufacturing amorphous paroxetine hydrochloride by mixing a carboxylic acid salt of paroxetine with hydrogen chloride and isolating the amorphous paroxetine hydrochloride. Also described herein are methods for manufacturing substantially pure paroxetine free base and methods for obtaining paroxetine salts such as paroxetine acetate, paroxetine trifluoroacetate, and paroxetine formate. Also described are methods for preparing paroxetine carbonate, paroxetine phosphate, paroxetine sulfate, and analogous salts thereof. The paroxetine salts may be formulated for the treatment of medical disorders as described.

  本文描述了制造非晶态盐酸帕罗西汀的方法，包括将帕罗西汀的羧酸盐与氯化氢混合并分离出非晶态盐酸帕罗西汀。还描述了制造基本纯净的帕罗西汀自由基的方法，以及获取帕罗西汀醋酸盐、帕罗西汀三氟乙酸盐和帕罗西汀甲酸盐的方法。还描述了制备帕罗西汀碳酸盐、帕罗西汀磷酸盐、帕罗西汀硫酸盐及其类似盐的方法。这些帕罗西汀盐可用于治疗医疗疾病。
• SALTS OF PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1053234A1

  公开（公告）日：2000-11-22
• [EN] SALTS OF PAROXETINE<br/>[FR] SELS DE PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO1999040084A1

  公开（公告）日：1999-08-12

  (EN) A salt of paroxetine with an acid selected from the group consisting of sulphuric, tartaric, oxalic, fumaric, propionic, formic, glutamic, succinic, benzoic, citric, nitric, phosphoric, 4-methylbenzenesulphonic, hypophosphorous, lactic, and mandelic acids and glycine, is useful in the treatment and prophylaxis of certain CNS disorders.(FR) L'invention concerne des sels de paroxétine avec un acide sélectionné dans le groupe constitué d'acides sulfurique, tartrique, oxalique, fumarique, propionique, formique, glutamique, succinique, benzoïque, nitrique, phosphorique, 4-méthylbenzène sulfonique, hypophosphoreux, lactique et mandélique ainsi que de glycine. Ce sel peut servir au traitement et à la prévention de certains troubles du système nerveux central.
• [EN] OPTIMIZED PROCEDURES FOR THE MANUFACTURE OF PAROXETINE SALTS<br/>[FR] PROCEDURES OPTIMISEES POUR LA FABRICATION DE SELS DE PAROXETINE
  申请人：PENTECH PHARMACEUTICALS INC

  公开号：WO2002085360A1

  公开（公告）日：2002-10-31

  Described herein are methods for manufacturing amorphous paroxetine hydrochloride by mixing a carboxylic acid salt of paroxetine with hydrogen chloride and isolating the amorphous paroxetine hydrochloride. Also described herein are methods for manufacturing substantially pure paroxetine free base and methods for obtaining paroxetine salts such as paroxetine acetate, paroxetine trifluoroacetate, and paroxetine formate. Also described are methods for preparing paroxetine carbonate, paroxetine phosphate, paroxetine sulfate, and analogous salts thereof. The paroxetine salts may be formulated for the treatment of medical disorders as described.