methyl (3R,4R)-4-(4-fluorophenyl)-1-methylpiperidine-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: methyl (3R,4R)-4-(4-fluorophenyl)-1-methylpiperidine-3-carboxylate
• 化学式: C₁₄H₁₈FNO₂
• 分子量: 251.3
• InChiKey: NTYATEQGMUSJQM-STQMWFEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• PREPARATION OF PAROXETINE HYDROCHLORIDE HEMIHYDRATE
  申请人：Thippannachar Mathad Vijayavitthal

  公开号：US20060264637A1

  公开（公告）日：2006-11-23

  A process for preparing paroxetine hydrochloride hemihydrate.

  制备帕罗西汀盐酸盐半水合物的工艺。
• Process for the preparation of enantiomerically enriched cyclic beta-aryl or heteroaryl carbocyclic acids
  申请人：Bachmann Stephan

  公开号：US20070232653A1

  公开（公告）日：2007-10-04

  The present invention relates to a process for the preparation of cis substituted cyclic β-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with the following scheme wherein X, Ar, n, and m are defined herein and corresponding salts thereof.

  本发明涉及一种通过对下列方案进行对映选择性氢化反应，制备高对映异构体和对映选择性的顺式取代的环状β-芳基或杂芳基羧酸衍生物的方法，其中X、Ar、n和m在此定义，并且包括相应的盐。
• [EN] PROCESS FOR THE PREPARATION OF PAROXETINE<br/>[FR] PROCEDE DE PREPARATION DE PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2001029031A1

  公开（公告）日：2001-04-26

  Three process schemes (1), (2) and (3) for a complete route to paroxetine from a pyridine ester are disclosed.

  披索西汀从吡啶酯完整路线的三种工艺方案（1）、（2）和（3）被披露。
• PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED CYCLIC BETA-ARYL OR HETEROARYLCARBOCYCLIC ACIDS
  申请人：Bachmann Stephan

  公开号：US20110105758A1

  公开（公告）日：2011-05-05

  The present invention relates to a process for the preparation of cis substituted cyclic β-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with the following scheme wherein X, Ar, n, and m are defined hereinand corresponding salts thereof.

  本发明涉及一种通过对以下图示反应进行对映选择性氢化，以高对映异构体和对映选择性制备顺式取代的环状β-芳基或杂芳基羧酸衍生物的方法：其中X，Ar，n和m在此定义，并对应的盐。
• PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED CYCLIC BETA-ARYL OR HETEROARYL CARBOCYCLIC ACIDS
  申请人：Bachmann Stephan

  公开号：US20130253201A1

  公开（公告）日：2013-09-26

  The present invention relates to a process for the preparation of cis substituted cyclic β-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with the following scheme wherein X, Ar, n, and m are defined herein and corresponding salts thereof.

  本发明涉及一种制备具有高对映选择性和高顺式取代的环状β-芳基或杂芳基羧酸衍生物的过程，通过根据以下方案进行对映选择性加氢，其中X，Ar，n和m在此定义，并且它们的相应盐。