3-[2-(Cyclopropylmethyl)-2-azabicyclo[3.3.1]nonan-5-yl]benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-[2-(Cyclopropylmethyl)-2-azabicyclo[3.3.1]nonan-5-yl]benzamide
• 化学式: C₁₉H₂₆N₂O
• 分子量: 298.4
• InChiKey: YYKPKDVDDDHICQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 2-Azabicyclo[3.3.1]nonane derivatives
  申请人：Pfizer Inc.

  公开号：US20040204445A1

  公开（公告）日：2004-10-14

  The subject invention relates to 2-azabicyclo[3.3.1]nonane derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by opioid receptors. The subject invention also particularly relates to using such derivatives to treat certain disorders and conditions, for example irritable bowel syndrome, drug addiction, including alcohol addiction, depression, anxiety, schizophrenia and eating disorders, among others, as are more fully described herein.

  该发明涉及2-氮杂双环[3.3.1]壬烷衍生物，包括这些衍生物的药物组合物以及使用这些衍生物来治疗由阿片受体介导的疾病状态、障碍和症状的方法。该发明还特别涉及使用这些衍生物来治疗某些障碍和症状，例如肠易激综合征、药物成瘾（包括酒精成瘾）、抑郁症、焦虑症、精神分裂症和进食障碍等，如本文所述。
• [EN] 2-AZABICYCLO[3.3.1]NONANE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE 2-AZABICYCLO[3.3.1]NONANE UTILISES COMME ANTAGONISTES DES RECEPTEURS OPIOIDES
  申请人：PFIZER PROD INC

  公开号：WO2004089909A1

  公开（公告）日：2004-10-21

  The subject invention relates to 2-azabicyclo[3.3.1 ]nonane derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by opioid receptors. The subject invention also particularly relates to using such derivatives to treat certain disorders and conditions, for example irritable bowel syndrome, drug addiction, including alcohol addiction, depression, anxiety, schizophrenia and eating disorders, among others, as are more fully described herein. Formula (I):

  本发明涉及2-azabicyclo [3.3.1]非缩酮衍生物，包括这种衍生物的制药组合物以及使用这种衍生物治疗由阿片受体介导的疾病状态，紊乱和病况的方法。本发明特别涉及使用这种衍生物治疗某些紊乱和病况，例如肠易激综合症，药物成瘾，包括酒精成瘾，抑郁症，焦虑症，精神分裂症和进食紊乱等，如本文所述。公式（I）：
• EP1615893A1
  申请人：——

  公开号：EP1615893A1

  公开（公告）日：2006-01-18
• US7056930B2
  申请人：——

  公开号：US7056930B2

  公开（公告）日：2006-06-06
• USRE40838E1
  申请人：——

  公开号：USRE40838E1

  公开（公告）日：2009-07-07