alpha-Bencynonatine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: alpha-Bencynonatine
• 英文别名: (3-methyl-3-azabicyclo[3.3.1]nonan-9-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate
• 化学式: C₂₂H₃₁NO₃
• 分子量: 357.5
• InChiKey: ROZOEEGFKDFEFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SELECTIVE M4 RECEPTOR ANTAGONIST AND ITS MEDICAL USE
  申请人：Zhong Bohua

  公开号：US20110306633A1

  公开（公告）日：2011-12-15

  The present invention provides a selective M4 receptor antagonist, levorotatory demethylated phencynonate or its nontoxic pharmaceutically acceptable salt, a pharmaceutical composition comprising this compound, and a use thereof in the manufacture of a medicament for the treatment of motion dysfunction, such as, tremor, rigor and the like caused by Parkinson's disease (PD). The structure, of the compound is shown in Formula IIa:

  本发明提供了一种选择性M4受体拮抗剂，左旋去甲基苯环酮或其无毒的药学上可接受的盐，包含该化合物的药物组合物，以及在制备用于治疗帕金森病（PD）引起的运动功能障碍，如震颤、僵直等的药物中的用途。该化合物的结构如公式IIa所示。
• A COMPOSITION FOR PREVENTING AND TREATING KINETOTIA SYNDROME
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A.

  公开号：EP0734724A1

  公开（公告）日：1996-10-02

  The invention relates to a pharmaceutical composition for preventing and/or treating kinetotia syndrome, method for treatment of kinetotia syndrome thereof, and method of preparing α-configuration benzene ring ester hydrochloride as active component of the pharmaceutical composition. The pharmaceutical composition according to the invention shows more effective with lower side-effect, compared with known medicines used to treat kinetotia syndrome. Furthermore, the pharmaceutical composition according to the invention is useful for preventing and/or treating various conditions, such as, centric and peripheral choline dysfunction caused by centric and peripheral hyperacetylcholine.

  本发明涉及一种预防和/或治疗动眼神经综合征的药物组合物、治疗动眼神经综合征的方法，以及制备作为药物组合物活性成分的α-构型苯环酯盐酸盐的方法。与用于治疗动眼神经畸形综合征的已知药物相比，本发明的药物组合物疗效更好，副作用更小。此外，根据本发明的药物组合物还可用于预防和/或治疗各种疾病，如中心和外周高乙酰胆碱引起的中心和外周胆碱功能障碍。
• PROCESS FOR THE PREPARATION OF A PHENCYNONATE HYDROCHLORIDE OF ALPHA-CONFIGURATION
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A.

  公开号：EP0734724B1

  公开（公告）日：2003-08-20