(3S)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3S)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine
• 化学式: C₁₉H₂₀FNO₃
• 分子量: 329.4
• InChiKey: AHOUBRCZNHFOSL-MBIQTGHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  39.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] SYSTEM FOR FLUORINATING ORGANIC COMPOUNDS<br/>[FR] SYSTÈME DE FLUORATION DE COMPOSÉS ORGANIQUES
  申请人：HARVARD COLLEGE

  公开号：WO2009100014A1

  公开（公告）日：2009-08-13

  Described herein are fluorinated organic compounds and methods of making fluorinated organic compounds, for example, using palladium complexes. Also described herein are compositions and kits containing compounds and palladium complexes described herein.

  本文描述了氟化有机化合物及制备氟化有机化合物的方法，例如使用钯配合物。本文还描述了含有上述化合物和钯配合物的组合物和试剂盒。
• [EN] HIGH-VALENT PALLADIUM FLUORIDE COMPLEXES AND USES THEREOF<br/>[FR] COMPLEXES DE FLUORURE DE PALLADIUM DE VALENCE ÉLEVÉE ET LEURS UTILISATIONS
  申请人：HARVARD COLLEGE

  公开号：WO2009149347A1

  公开（公告）日：2009-12-10

  The present invention provides novel high-valent palladium fluoride complexes. The complexes typically include multi-dentate ligands that stabilize the octahedral coordination sphere of the palladium(IV) atom. These complexes are useful in fluorinating organic compounds, in particular aryl-containing compounds. The invention is particularly useful for fluorinating compounds with 19F for PET imaging.

  本发明提供了新颖的高价钯氟化物配合物。这些配合物通常包括多齿配体，稳定钯（IV）原子的八面体配位球。这些配合物在氟化有机化合物方面很有用，特别是含芳基的化合物。该发明特别适用于用于PET成像的含19F的化合物的氟化。
• [EN] AN IMPROVED PROCESS FOR MINIMISING THE FORMATION OF DEHALOGENATED BYPRODUCTS<br/>[FR] PROCÉDÉ AMÉLIORÉ PERMETTANT DE RÉDUIRE AU MINIMUM LA FORMATION DE SOUS-PRODUITS DÉSHALOGÉNÉS
  申请人：PIRAMAL ENTPR LTD

  公开号：WO2015071831A1

  公开（公告）日：2015-05-21

  The present invention provides an improved process for preparation of organic compounds represented by Formula-Z; wherein effectively minimising the formation of dehalogenated by-products is achieved. In the process, the reduction is carried out using suitable reducing agent; more preferably Lithium Aluminium Hydride (LAH) in a solvent system, wherein at least one of the solvent is selected from halogenated solvents, which acts as co-solvent. The process of the present invention is useful for minimising of the formation of dehalogenated by-products during synthesis of various active pharmaceutical ingredients such as Paroxetine Hydrochloride, Cinacalcet, Eletriptan and Asenapine.

  本发明提供了一种改进的有机化合物制备方法，该化合物由FormuLA-Z表示；在该过程中，有效地最小化了去卤代副产物的形成。在该过程中，使用适当的还原剂进行还原；更好地使用锂铝氢化物（LAH）在溶剂系统中进行还原，其中至少一种溶剂是选自卤代溶剂的协溶剂。本发明的方法对于在合成各种活性药物成分（如盐酸帕罗西汀、西那卡塞特、厄利替普坦和阿塞那平）期间最小化去卤代副产物的形成非常有用。
• Combination therapy for dementia, depression and apathy
  申请人：Sheldon James Leslie

  公开号：US20060287299A1

  公开（公告）日：2006-12-21

  The invention provides, in part, methods and compositions for treating psychiatric disorders, for example, apathy, dementia, or depression, using combination therapies such a monoamine oxidase inhibitor or a selective serotonin reuptake inhibitor in combination with an anti-psychotic agent.

  本发明提供了治疗精神障碍的方法和组合物，例如，使用单胺氧化酶抑制剂或选择性血清素再摄取抑制剂与抗精神病药物等组合疗法治疗无动于衷、痴呆或抑郁等精神障碍。
• SYSTEM FOR FLUORINATING ORGANIC COMPOUNDS
  申请人：President and Fellows of Harvard College

  公开号：US20140058106A1

  公开（公告）日：2014-02-27

  Described herein are fluorinated organic compounds and methods of making fluorinated organic compounds, for example, using palladium complexes. Also described herein are compositions and kits containing compounds and palladium complexes described herein.

  本文描述了氟化有机化合物及制备氟化有机化合物的方法，例如使用钯配合物。本文还描述了包含所述化合物和钯配合物的组合物和工具包。