(S)-1-Boc-3-哌啶乙腈 | 1217710-12-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: (S)-1-Boc-3-哌啶乙腈
• 英文名称: (S)-tert-butyl 3-(cyanomethyl)piperidine-1-carboxylate
• 英文别名: tert-butyl (3S)-3-(cyanomethyl)piperidine-1-carboxylate
• CAS: 1217710-12-7
• 化学式: C₁₂H₂₀N₂O₂
• 分子量: 224.303
• InChiKey: RWAQULYYWNUYFH-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  53.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• N-ACYL CYCLIC AMINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
  申请人：Maruyama Megumi

  公开号：US20120214790A1

  公开（公告）日：2012-08-23

  The present invention provides compounds which show high effectiveness against positive symptoms, negative symptoms and cognitive dysfunction in schizophrenia and reduce conventional side-effect risks as well as have remarkable effects for central neurological diseases associated with cognitive dysfunction other than schizophrenia. N-Acyl cyclic amine derivatives of formula (1): wherein Ar 1 and Ar 2 are aryl or heteroaryl; V is nitrogen, or CR 3 ; W 1 is a single bond, —C(O)—, etc.; W 2 is C 1 -alkylene; W 3 is a single bond, methylene, —NH—, —CR 4 ═CR 5 —, etc.; Ring Q is a group of formula (a) in which n is 0 or 1; m is 0 to 2; k is 1 to 3; Z is a single bond, methylene, oxygen, etc.; R 1a , R 1b and R 1c are each, same or different, hydrogen, hydroxyl, halogen, cyano, C 1-6 alkyl, etc.; or pharmaceutically acceptable salts thereof are provided.

  本发明提供了化合物，对于精神分裂症的阳性症状、阴性症状和认知功能障碍表现出高效性，并且降低了传统副作用风险，对于除精神分裂症以外的与认知功能障碍相关的中枢神经系统疾病具有显著的效果。公式（1）中的N-酰基环状胺衍生物，其中Ar1和Ar2是芳基或杂环芳基；V是氮或CR3；W1是单键，-C(O)-等；W2是C1-烷基；W3是单键，亚甲基，-NH-，-CR4═CR5-等；环Q是公式（a）的基团，在其中n为0或1；m为0到2；k为1到3；Z是单键，亚甲基，氧等；R1a，R1b和R1c分别相同或不同，是氢，羟基，卤素，氰基，C1-6烷基等；或其药学上可接受的盐。
• Azaquinazoline Inhibitors of Atypical Protein Kinase C
  申请人：Cancer Research Technology Limited

  公开号：US20160102094A1

  公开（公告）日：2016-04-14

  The present application provides a compound of formula (1) or a salt thereof, wherein R 7 , R 8 , R 9 , G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative diseases.

  本申请提供了一个公式（1）的化合物或其盐，其中R7、R8、R9、G和X的定义如本文所述。本申请进一步描述了包含这些化合物的组合物。公式（I）的化合物及其盐具有aPKC抑制活性，并可用于治疗增殖性疾病。
• KRAS G12C INHIBITORS
  申请人：Mirati Therapeutics, Inc.

  公开号：US20180072723A1

  公开（公告）日：2018-03-15

  The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
• US8541585B2
  申请人：——

  公开号：US8541585B2

  公开（公告）日：2013-09-24
• US9896446B2
  申请人：——

  公开号：US9896446B2

  公开（公告）日：2018-02-20