2-[[4-[(Diethylsulfamoylamino)methyl]cyclohexyl]amino]-4,5-dihydro-[1]benzothiepino[5,4-d][1,3]thiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫平类
• 英文名称: 2-[[4-[(Diethylsulfamoylamino)methyl]cyclohexyl]amino]-4,5-dihydro-[1]benzothiepino[5,4-d][1,3]thiazole
• 化学式: C₂₂H₃₂N₄O₂S₃
• 分子量: 480.7
• InChiKey: IRRGZJQQZQFTKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  136
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Selective NPY (Y5) antagonists
  申请人：Marzabadi R. Mohammad

  公开号：US20050137240A1

  公开（公告）日：2005-06-23

  This invention is directed to bicyclic and tricyclic compounds which are selective antagonists for NPY (Y5) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of this invention and a pharmaceutically acceptable carrier. The invention provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides the use of a compound of the invention for the preparation of a pharmaceutical composition for treating an abnormality, wherein the abnormality is alleviated by decreasing the activity of a human Y5 receptor.

  本发明涉及选择性拮抗NPY（Y5）受体的双环和三环化合物。本发明提供一种制药组合物，包括本发明化合物的治疗有效量和药学上可接受的载体。本发明提供了一种由本发明化合物的治疗有效量和药学上可接受的载体组合而成的制药组合物。本发明还提供了制备制药组合物的方法，包括将本发明化合物的治疗有效量和药学上可接受的载体组合。本发明进一步提供了使用本发明化合物制备用于治疗异常状态的制药组合物，其中减少人类Y5受体活性可缓解该异常状态。
• SELECTIVE NPY (Y5) ANTAGONISTS
  申请人：H. LUNDBECK A/S

  公开号：EP1194421B1

  公开（公告）日：2005-10-12
• US6222040B1
  申请人：——

  公开号：US6222040B1

  公开（公告）日：2001-04-24
• US7273880B2
  申请人：——

  公开号：US7273880B2

  公开（公告）日：2007-09-25