2-ethenylsulfonyl-N-[[(2-ethenylsulfonylacetyl)amino]methyl]acetamide

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 2-ethenylsulfonyl-N-[[(2-ethenylsulfonylacetyl)amino]methyl]acetamide
• 化学式: C₉H₁₄N₂O₆S₂
• 分子量: 310.4
• InChiKey: UBAYCXUHTIFBKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  143
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Analytical element for enzyme immunoassays
  申请人：FUJIREBIO KABUSHIKI KAISHA

  公开号：EP0310940A2

  公开（公告）日：1989-04-12

  A dry-type analytical element for immunoassay having at least one water-permeable layer for measuring a ligand in a sample according to enzyme immunoassay, which comprises, (A) a water-soluble macromolecular substrate, and (B) an enzyme conjugated with antibody reacting with the ligand in the sample capable to act on the above water-soluble macromolecular substrate. The above analytical element further comprises, (C) a macromolecular antigen which is a conjugate of the ligand or its derivative with a macromolecular compound in the above water-permeable layer of the above dry-type analytical element. The invention can conduct highly sensitive and simple enzyme immunoassay.

  一种用于免疫测定的干式分析元件，具有至少一个透水层，用于根据酶免疫测定法测量样品中的配体，该元件包括 (A) 水溶性大分子底物，和 (B) 与样品中配体反应的抗体结合的酶，能够作用于上述水溶性大分子底物。 上述分析元件还包括 (C) 大分子抗原，它是配体或其衍生物与上述干式分析元件的上述透水层中的大分子化合物的共轭物。 本发明可进行高灵敏度、简便的酶免疫检测。
• Dry analytical element and process for producing the same
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0333114A1

  公开（公告）日：1989-09-20

  A dry analytical element for use in detecting a specific component contained in a liquid, which element comprises one or more water permeable layers provided on a water impermeable support, at least one layer of the water-permeable layers containing a composition capable of interacting with said specific component contained in said liquid. The composition contains a leuco dye and a dispersion containing said leuco dye is incorporated in the water-permeable layer, which is formed by dissolving the leuco dye in a hydrophobic solvent containing an aliphatic higher alcohol and dispersing the resulting solution in a hydrophilic medium. The leuco dye has the formula: wherein R¹ represents an unsubstituted or substituted aryl group, R² represents an unsubstituted or substituted alkyl group, and R³ represents an unsubstituted or substituted aryl group. A process for producing said dry analytical element is also disclosed.

  一种用于检测液体中所含特定成分的干式分析元件，该元件包括一个或多个透水层，设置在不透水的支架上，透水层中至少有一层含有能与所述液体中所含特定成分相互作用的成分。组合物中含有一种白兰地染料，透水层中含有白兰地染料的分散液，该分散液是通过将白兰地染料溶解在含有脂肪族高级醇的疏水性溶剂中，并将所得溶液分散在亲水性介质中形成的。白兰地染料的化学式如下 其中 R¹ 代表未取代或取代的芳基，R² 代表未取代或取代的烷基，R³ 代表未取代或取代的芳基。还公开了一种生产所述干分析元素的工艺。
• Dry-type analytical element for immunoassay
  申请人：FUJIREBIO KABUSHIKI KAISHA

  公开号：EP0347839A2

  公开（公告）日：1989-12-27

  A dry-type analytical element for immunoassay having at least one water-permeable layer for measuring a ligand in a sample according to enzyme immunoassay, which comprises, (A) a water-insoluble macromolecular substrate, and (B) an antibody, reacting with the ligand in the sample, conjugated with an enzyme capable of acting on the above water-insoluble macromolecular substrate. The above analytical substance further comprises, (C) a macromolecular substance which is a conjugate of the ligand or its derivative with a macromolecular compound in the above water-permeable layer of the above dry-type analytical element. The invention can conduct a highly sensitive and simple enzyme immunoassay.

  一种用于免疫测定的干式分析元件，具有至少一层透水层，用于根据酶免疫测定法测量样品中的配体，该元件包括 (A) 不溶于水的大分子底物，和 (B) 与样品中配体反应的抗体，抗体与能作用于上述不溶于水的大分子底物的酶结合。上述分析物质还包括 (C) 大分子物质，它是配体或其衍生物与上述干式分析元件的上述透水层中的大分子化合物的共轭物。 本发明可进行高灵敏度和简单的酶免疫测定。
• Analytical element for whole blood
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0382207A2

  公开（公告）日：1990-08-16

  An integral multilayer analytical element which comprises a first fibrous porous layer, a nonfibrous porous layer, and a second fibrous porous layer superposed in this order on a water-impermeable light-transmissive support. The above three porous layers are integrally laminated to each other substantially closely by an adhesive discontinuously disposed so as to form microspaces continuing through from one layer to the next so as not to interfere with the approximately uniform permeation of liquid. A reagent composition which produces an optically detectable change in the presence of an analyte is incorporated in at least one of said three porous layers. On the other hand, when a nonporous reagent layer is incorporated on the support in the above analytical element, the reagent composition is incorporated in the nonporous reagent layer. By using the analytical element of the invention, the analytical values of various analytes of blood samples can be obtained independently of hematocrit values from whole blood samples and blood plasma samples in the range of the hematocrit values of 0 % to 55 %.

  一种整体多层分析元件，它包括一个第一纤维多孔层、一个非纤维多孔层和一个第二纤维多孔层，依次叠加在一个不透水的透光支架上。上述三层多孔层通过不连续布置的粘合剂紧密地整体层叠在一起，以形成从一层延伸到下一层的微空间，从而不影响液体近似均匀的渗透。在上述三层多孔层中的至少一层中加入了一种试剂成分，这种试剂成分在分析物存在的情况下会产生光学可检测的变化。另一方面，当在上述分析元件中的支架上加入无孔试剂层时，试剂组合物就会加入无孔试剂层中。通过使用本发明的分析元件，可以在血细胞比容值为 0 % 至 55 % 的范围内，从全血样本和血浆样本中独立获得血液样本中各种分析物的分析值。
• Dry analysis element for quantitative analysis of analyte contained in whole blood
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0423784A2

  公开（公告）日：1991-04-24

  A dry analysis element for the quantitative analysis of an analyte contained in whole blood comprises a layer exhibiting volume filtration function and a detection layer. The layer exhibiting volume filtration function is made of a cloth selected from microfibrous cloths each having an averagte fiber diameter of from 0.1 to 10 µm or a napped cloth having an average of from 1 to 30 µm. In a first preferred embodiment, the layer exhibiting volume filtration function is composed of a non-woven cloth having a density of from 0.01 to 0.2 g/cm³ and made of fibers each having an average fiber diameter of from 0.2 to 10 µm. In a second preferred embodiment, the layer exhibiting volume filtration function is composed of a napped cloth having a fiber density per cm² of from 7.0 x 10³ to 8.2 x 10⁶, each of the napped fibers having an average diameter of from 1 to 30 microns and an average nap length of 0.5 to 5.0 mm. In a third preferred embodiment, the layer exhibiting volume filtration function is composed of a cloth having a porosity of from 45 to 70% and made of micro filaments each having an average filament diameter of from 0.1 to 7 µm.

  一种用于定量分析全血中所含分析物的干式分析元件包括一个具有体积过滤功能的层和一个检测层。具有体积过滤功能的层由微纤维布制成，微纤维布的平均纤维直径为 0.1 至 10 微米，或由平均纤维直径为 1 至 30 微米的绒布制成。在第一个优选实施方案中，具有体积过滤功能的层由密度为 0.01 至 0.2 克/立方厘米的无纺布组成，由平均纤维直径为 0.2 至 10 微米的纤维制成。在第二种优选实施方式中，具有体积过滤功能的层由纤维密度为每平方厘米 7.0 x 10³ 至 8.2 x 10⁶ 的绒布组成，每根绒布纤维的平均直径为 1 至 30 微米，平均绒毛长度为 0.5 至 5.0 毫米。在第三种优选的实施方案中，具有体积过滤功能的层由孔隙率为 45% 至 70% 的布组成，由平均丝径为 0.1 至 7 微米的微丝制成。