3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4H-thieno[3,2-c][1]benzothiepin-9-yl)propanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫平类
• 英文名称: 3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4H-thieno[3,2-c][1]benzothiepin-9-yl)propanamide
• 化学式: C₁₆H₁₂F₃NO₅S₂
• 分子量: 419.4
• InChiKey: NAFSYPCVPLWHFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• MEDICINAL COMPOSITION
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1649855A1

  公开（公告）日：2006-04-26

  The present invention provides a pharmaceutical composition which is useful in the treatment for bladder irritative symptoms accompanied by benign prostatic hyperplasia and the like, and comprises 3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c] [1]benzothiepin-9-yl)propanamide or a pharmaceutically acceptable salt thereof, and an α1-adrenoceptor antagonist.

  本发明提供了一种药物组合物，可用于治疗伴随良性前列腺增生等症状的膀胱刺激症状，该药物组合物包含3,3,3-三氟-2-羟基-2-甲基-N-(5,5,10-三氧代-4,10-二氢噻吩并[3,2-c] [1]苯并噻吩-9-基)丙酰胺或其药学上可接受的盐，以及α1-肾上腺素受体拮抗剂。
• TRICYCLIC COMPOUNDS
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP0979821B1

  公开（公告）日：2006-09-13
• MICROCRYSTAL AND MEDICINAL PREPARATION CONTAINING THE SAME
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1693374B1

  公开（公告）日：2008-10-15
• JP2009067768A
  申请人：——

  公开号：JP2009067768A

  公开（公告）日：2009-04-02
• Agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia
  申请人：——

  公开号：US20040122078A1

  公开（公告）日：2004-06-24

  The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K + channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K + channel opening activity as an index.