6-Methoxy-1-methyl-7-[[(2-phenylpiperidin-3-yl)amino]methyl]-1-(trifluoromethyl)-3,4-dihydroisochromen-4-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 6-Methoxy-1-methyl-7-[[(2-phenylpiperidin-3-yl)amino]methyl]-1-(trifluoromethyl)-3,4-dihydroisochromen-4-ol
• 化学式: C₂₄H₂₉F₃N₂O₃
• 分子量: 450.5
• InChiKey: GOMVBYMXBOFLQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  62.8
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• 1-TRIFLUOROMETHYL-4-HYDROXY-7-PIPERIDINYL-AMINOMETHYLCHROMAN DERIVATIVES
  申请人：Pfizer Products Inc.

  公开号：EP1178984A2

  公开（公告）日：2002-02-13
• US6239147B1
  申请人：——

  公开号：US6239147B1

  公开（公告）日：2001-05-29
• [EN] 1-TRIFLUOROMETHYL-4-HYDROXY-7-PIPERIDINYL-AMINOMETHYLCHROMAN DERIVATIVES<br/>[FR] DERIVES 1-TRIFLUOROMETHYL-4-HYDROXY-7-PIPERIDINYL-AMINOMETHYLCHROMANE
  申请人：PFIZER PROD INC

  公开号：WO2000071538A2

  公开（公告）日：2000-11-30

  This invention relates to novel 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives of formula (I) wherein R1 is C1-C6 alkyl; R2 is hydrogen, C¿1?-C6 alkyl, halo C1-C6 alkyl or phenyl; R?3¿ is hydrogen or halo; and R?4 and R5¿ are independently hydrogen, C¿1?-C6 alkyl or halo C1-C6 alkyl, their pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and the use of such compounds to treat CNS, gastrointestinal and other disorders.