tert-butyl (3S,4S)-3,4-dihydroxy-4-(4-methoxyphenyl)piperidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl (3S,4S)-3,4-dihydroxy-4-(4-methoxyphenyl)piperidine-1-carboxylate
• 化学式: C₁₇H₂₅NO₅
• 分子量: 323.4
• InChiKey: JPQFMFJPCMUEBO-YOEHRIQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  79.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] PROCESS FOR THE PREPARATION OF SUBSTITUTED PIPERIDINES<br/>[FR] PROCEDE DE PREPARATION DE PIPERIDINES SUBSTITUEES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2000063173A1

  公开（公告）日：2000-10-26

  The present invention concerns a process for the preparation of a compound of formula (1) or salts thereof, comprising the reaction of a compound of formula (2) in the presence of an oxidant and a chiral osmium complex, wherein the hydroxy groups attached to the carbon atoms 3 and 4 of the piperidine cycle of formula (1) are in cis position and A, R?1 and R2¿ are as defined in the description and claims.