(三甲基亚磷酸酯)金(I)氯化物 | 33634-99-0

• 分子结构分类: 有机化合物 - 有机磷化合物 - 亚磷酸三烷基酯
• 中文名称: (三甲基亚磷酸酯)金(I)氯化物
• 英文名称: chloro(trimethylphosphite)gold(I)
• 英文别名: chlorogold;trimethyl phosphite
• CAS: 33634-99-0
• 化学式: C₃H₉AuClO₃P
• 分子量: 356.496
• InChiKey: CADCHRBXMXCBFL-UHFFFAOYSA-M

物化性质

• 熔点：
  98-100°C

计算性质

• 辛醇/水分配系数(LogP)：
  1.84
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (三甲基亚磷酸酯)金(I)氯化物 在 吡啶 、 吡啶硼烷 作用下， 反应 48.0h， 生成 gold
  参考文献：
  名称：

  Gold nanostructures - assisted laser desorption/ionization mass spectrometry for kidney cancer blood serum biomarker screening

  摘要：

  Kidney cancer is a disease diagnosed annually in 400,000 people for which there are no specific biomarkers found to date. It is therefore important to search for new chemical compounds to detect cancer state. Laser desorption/ionization mass spectrometry on gold nanoparticle-enhanced target (AuNPET) method was used in this work for rapid metabolic analysis of blood serum of fifty patients with renal cancer. Comparison with data from sera of fifty healthy volunteers allowed discovering potential biomarkers of renal cell carcinoma (RCC). Statistical analysis of m/z values that had the greatest impact on group differentiation allowed. Database search allowed providing assignment of signals for the most promising eleven features among them: dihydrouracil, creatinine, glutamine, tyrosine, 2,3-diaminosalicylic acid, 3-hydroxykynurenine, 2-hydroxylauroylcarnitine, melatonin glucuronide, palmitoyl glucuronide, triglyceride(52:4) or phosphatidylcholine(42:0). This work demonstrate that the differences in metabolite profiles in serum of kidney cancer patients and that of healthy subjects could be identified by gold nanostructures LDI MS - based metabolomics and exploited as metabolic serum markers for the early detection of kidney cancer. (C) 2020 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ijms.2020.116396
• 作为产物：
  描述：

  甲醇 在 PCl₃AuCl 作用下， 生成 (三甲基亚磷酸酯)金(I)氯化物
  参考文献：
  名称：

  Lindet, Annales de Chimie (Cachan, France), 1887, vol. <6> 11, p. 190

  摘要：

  DOI：

文献信息

• Synthesis and Characterization of Gold Silyl Compounds with Different Phosphine or Phosphite Groups for Reduction Reactions
  作者：Sebastian Kenzler、Matthias Kotsch、Andreas Schnepf

  DOI：10.1002/ejic.201800595

  日期：2018.9.16

  The synthesis and structural characterization of metalloid gold clusters stabilized by sulfur ligands has increased massively in the last decade. The metalloid gold clusters are synthesized via a reduction of a gold precursor and most metalloid gold clusters are stabilized via aryl thiolate ligands. It is also possible to use thiosilyl or phosphine groups as stabilizing ligands. Here, we present a

  在过去的十年中，由硫配体稳定的准金属金簇的合成和结构表征得到了极大的提高。准金属金簇通过还原金前体而合成，并且大多数准金属金簇通过芳基硫醇盐配体稳定。也可以使用硫代甲硅烷基或膦基作为稳定配体。在这里，我们提出了一个小的Au 6团簇，作为形成大型准金属簇团的可能中间产物，以及合成了各种定义的Au 1前体，这些前体包含膦或亚磷酸酯基团以及硫代甲硅烷基配体，可以可进一步用于合成准金属金簇。
• Entry to β-Alkoxyacrylates via Gold-Catalyzed Intermolecular Coupling of Alkynoates and Allylic Ethers
  作者：Sae Rom Park、Cheoljae Kim、Dong-gil Kim、Neetipalli Thrimurtulu、Hyun-Suk Yeom、Jungho Jun、Seunghoon Shin、Young Ho Rhee

  DOI：10.1021/ol4001087

  日期：2013.3.15

  The first gold-catalyzed intermolecular coupling of alkynoates and allylic ethers invoking alkoxy addition and [3,3]-sigmatropic rearrangement as the key mechanism has been developed. Remarkably, the reaction showed complete chemoselectivity toward the pathway initiated by the alkoxy addition to alkynes. This unprecedented reactivity led to a new access to diversely substituted β-alkoxyacrylates in

  已开发出第一个金催化的烷氧基化物和烯丙基醚的分子间偶联，其调用烷氧基加成和[3,3]-σ重排作为关键机理。显着地，该反应显示出对由烷氧基加成至炔烃引发的途径的完全化学选择性。这种空前的反应性使得人们可以高效地重新获得各种取代的β-烷氧基丙烯酸酯。
• Governing the oxidative addition of iodine to gold(i) complexes by ligand tuning
  作者：Daniel Schneider、Annette Schier、Hubert Schmidbaur

  DOI：10.1039/b403005b

  日期：——

  triakylphosphines (PMe3, PEt3) are readily oxidized, while those with more bulky ligands (PiPr3, PtBu3) are not. With L taken from the triarylphosphine series [PPh3, P(2-Tol)3, P(3-Tol3), P(4-Tol)3] no oxidation takes place at all, but mixed alkyl/aryl-phosphines [PMenPh3−n] induce oxidation for n = 3 and 2, but not for n = 1 and 0. However, in cases where no oxidation of the gold atoms is observed

  虽然已知几种（L）AuX（X = Cl，Br）类型的金（I）络合物会进行氧化加成元素氯和溴（X 2）分别得到相应的金（III）配合物（L）AuX 3，强烈向（碘）金（I）化合物中添加碘配体-依赖，表明氧化电位的关键阈值。对碘的这种特殊的氧化加成反应进行了系统的研究，使用了大量的叔膦 作为 配体L已表明，电子效应和位阻效应均会影响反应进程。反应之后31 P NMR光谱 和从中结晶出来的产品 二氯甲烷戊烷溶液。小triakylphosphines复合物（PME 3，PET 3）容易被氧化，而那些具有更笨重配体（P i Pr 3，P t Bu 3）不是。L来自三芳基膦系列[PPh 3，P（2-Tol）3，P（3-Tol 3），P（4-Tol）3 ]否氧化作用 发生，但混合 烷基/芳基膦[PMe n Ph 3- n ]诱导氧化作用对于n = 3和2，而不是对于n = 1和0。但是，如果没有氧化作用
• Gold(I)-Catalysed Hydroarylation of Lactam-Derived Enynes as an Entry to Tetrahydrobenzo[<i>g</i> ]quinolines
  作者：Stefano Nejrotti、Simone Ghinato、Elena C. Gini、Dina Scarpi、Ernesto G. Occhiato、Andrea Maranzana、Cristina Prandi

  DOI：10.1002/ejoc.201901599

  日期：2020.2.14

  The gold(I)‐catalysed cyclization of N‐tosyl‐protected 5‐benzyl‐6‐((trimethylsilyl)ethynyl)‐1,2,3,4‐tetrahydropyridines, prepared by Sonogashira coupling of lactam‐derived enol triflates, provides tetrahydrobenzo[g]quinolones. The Au(I)‐catalysed reaction is carried out with (C6F5)3PAuCl/AgNTf2 and proceeds via a 6‐exo‐dig cyclization to the aromatic tetrahydrobenzo[g]quinolines. The mode of cyclization

  由内酰胺衍生的烯醇三氟甲磺酸钠的Sonogashira偶合制备的金（I）催化的N-甲苯磺酰基保护的5-苄基-6-（（（三甲基甲硅烷基）乙炔基）1,2,3,4-四氢吡啶的环化反应提供四氢苯并[ g ]喹诺酮类。在Au（I） -催化的反应是用（C进行6 ˚F 5）3 PAuCl / AgNTf 2经由6-并且进行外切-挖环化为芳族四氢苯并[克]喹啉。DFT计算讨论并支持了环化模式。
• Synthesis and reactivity of mono- and hetero-nuclear rhodium(I) or iridium(I) complexes with 2-(2′-pyridyl)benzimidazole
  作者：Rafael Uson、Luis A. Oro、Javier A. Cabeza

  DOI：10.1016/s0022-328x(00)98835-1

  日期：1983.5

  Rhodium(I) and iridium(I) complexes of the formulae M(PyBzIm)(diolefin), [M(HPyBzIm)(diolefin)]ClO4, (diolefin)M(μ-PyBzIm)AuCl, [(diolefin)M(μ-PyBzIm)AuL]ClO4 (L = PPh3 or P(OMe)3), [(diolefin)M(μ-PyBzIm)AgPPh3]ClO4 and [AgM(μ-PyBzIm)(diolefin)2]ClO4 (diolefin = COD or NBD) are described. The related carbonyl derivatives M(PyBzIm)(CO)Y, [Rh(HPyBzIm)(CO)Y]ClO4 (Y = CO or PPh3), (CO)2 M(μ-PyBzIm)AuCl

  式M（PyBzIm）（二烯烃），[M（HPyBzIm）（二烯烃）] ClO 4，（二烯烃）M（μ-PyBzIm）AuCl，[（二烯烃）M（ μ-PyBzIm）AuL] ClO 4（L = PPh 3或P（OMe）3），[（二烯烃）M（μ-PyBzIm）AgPPh 3 ] ClO 4和[Ag M（μ-PyBzIm）（二烯烃）2描述了] ClO 4（二烯烃＝ COD或NBD）。相关的羰基衍生物M（PyBzIm）（CO）Y，[Rh（HPyBzIm）（CO）Y] ClO 4（Y = CO或P​​Ph 3），（CO）2 M（μ-PyBzIm）AuCl，[（CO）2 Rh（μ-PyBzIm）AuP（OMe）3 ] ClO 4，[Ag M;（μ-PyBzIm）（CO）22 ] CLO 4和[Au®h（μ-PyBzIm）（CO）2 2 ] CLO 4已经通过与一氧化碳和三苯基膦二烯烃衍生物的反应得到。