cis-1-(4-cyanobenzoyl)-3-fluorospiro[piperidine-4,2'(1'H)-quinazoline]-4'-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: cis-1-(4-cyanobenzoyl)-3-fluorospiro[piperidine-4,2'(1'H)-quinazoline]-4'-amine
• 英文别名: 4-(4-amino-3'-fluorospiro[1H-quinazoline-2,4'-piperidine]-1'-carbonyl)benzonitrile
• 化学式: C₂₀H₁₈FN₅O
• 分子量: 363.394
• InChiKey: URLBODMRSOHSNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  94.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel compounds
  申请人：——

  公开号：US20030064978A1

  公开（公告）日：2003-04-03

  There are provided novel compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the Specification and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.

  提供了一种化合物，其化学式为（I），其中R1、R2、R3、R4和R5如规范中所定义，并且包括其光学异构体、消旋体和互变异构体以及其药学上可接受的盐；以及它们的制备过程、含有它们的组合物以及它们在治疗中的应用。这些化合物是一氧化氮合酶的抑制剂。
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES
  申请人：ASTRAZENECA AB

  公开号：WO2001058867A2

  公开（公告）日：2001-08-16

  There are provided novel compounds of formula (I) wherein R?1, R2, R3, R4 and R5¿ are as defined in the Specification and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.