(1S,5S)-3-benzyl-3-azabicyclo[3.2.1]octan-8-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1S,5S)-3-benzyl-3-azabicyclo[3.2.1]octan-8-one
• 化学式: C₁₄H₁₇NO
• 分子量: 215.29
• InChiKey: DCDAOVIVXGHHHU-STQMWFEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS
  申请人：Ctxt Pty Ltd

  公开号：EP3189048A1

  公开（公告）日：2017-07-12
• [EN] AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS<br/>[FR] INHIBITEURS DE PRMT5 DÉRIVÉS D'AMINOINDANE, D'AMINOTÉTRAHYDRONAPHTHALÈNE ET D'AMINOBENZOCYCLOBUTANE
  申请人：CTXT PTY LTD

  公开号：WO2016034671A1

  公开（公告）日：2016-03-10

  A compound of formula (la), (lb) or (lc) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4a is selected from OH, -NH2, -C(=O)NH2, and -CH2OH; R4b is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.