(4Z)-5-methyl-2-phenyl-4-[(5-phenylfuran-2-yl)methylidene]pyrazol-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: (4Z)-5-methyl-2-phenyl-4-[(5-phenylfuran-2-yl)methylidene]pyrazol-3-one
• 化学式: C₂₁H₁₆N₂O₂
• 分子量: 328.4
• InChiKey: DHBHQWVCSSQXCP-RGEXLXHISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Methods and Compositions for Modulating P300/CBP Activity
  申请人：Marmorstein Ronen

  公开号：US20100216853A1

  公开（公告）日：2010-08-26

  The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.

  本发明涉及一种识别调节p300/CBP活性的化合物的方法。该发明的化合物是通过设计或筛选结合至新鉴定的赖氨酸-CoA抑制剂结合位点、L1环、电负性口袋或电负性槽的p300/CBP的HAT结构域的至少一个氨基酸残基的化合物来识别，并测试该化合物调节p300/CBP活性的能力。还提供了用于预防或治疗与p300/CBP相关的疾病或紊乱的组合物和方法，以及一种生产半合成HAT结构域的方法。
• US8476458B2
  申请人：——

  公开号：US8476458B2

  公开（公告）日：2013-07-02