1-(1-甲基哌啶-4-基)-1H-吡唑-5-胺 | 3524-30-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(1-甲基哌啶-4-基)-1H-吡唑-5-胺
• 中文别名: 2-(1-甲基-哌啶-4-基)-2H-3-氨基吡唑；2,6-二氯-4-(三氟甲氧)苯醋酸
• 英文名称: 1-(4-N-Methylpiperidyl)-5-amino-pyrazol
• 英文别名: 2-(1-methyl-piperidin-4-yl)-2H-pyrazol-3-ylamine；1-(1-methylpiperidin-4-yl)-1H-pyrazol-5-amine；2-(1-methylpiperidin-4-yl)pyrazol-3-amine
• CAS: 3524-30-9
• 化学式: C₉H₁₆N₄
• mdl: MFCD03856631
• 分子量: 180.253
• InChiKey: QCNNKYQIYTZXJX-UHFFFAOYSA-N

物化性质

• 熔点：
  129-130 °C
• 沸点：
  335.0±32.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  47.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

文献信息

• HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：EP3478675B1

  公开（公告）日：2020-04-22
• [EN] 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES<br/>[FR] 3-IMIDAZOLYL-INDOLES POUR TRAITER LES MALADIES PROLIFÉRATIVES
  申请人：NOVARTIS AG

  公开号：WO2012176123A1

  公开（公告）日：2012-12-27

  The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula (I), in which: R1, R2, R3 and R4 are as defined in the Summary of the Invention. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.