(3R)-3-methyl-1-methylsulfonylpiperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3R)-3-methyl-1-methylsulfonylpiperidine
• 化学式: C₇H₁₅NO₂S
• 分子量: 177.27
• InChiKey: LCTNPUZDOIMCGM-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] TRICYCLIC PYRAZOL AMINE DERIVATIVES<br/>[FR] DÉRIVÉS TRICYCLIQUES DE PYRAZOLAMINE
  申请人：MERCK SERONO SA

  公开号：WO2011058149A1

  公开（公告）日：2011-05-19

  This invention relates to compounds of Formula (I*) as Pi3k inhibitors for treating autoimmune diseases, inflammatory disorders, multiple sclerosis and other diseases like cancers.

  这项发明涉及到 Formula (I*) 的化合物作为 Pi3k 抑制剂，用于治疗自身免疫疾病、炎症性疾病、多发性硬化等疾病，以及癌症等其他疾病。
• [EN] PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES<br/>[FR] INHIBITEURS DE JAK3 DE TYPE PYRROLOPYRIDAZINE ET LEUR UTILISATION POUR TRAITER LES MALADIES INFLAMMATOIRES ET AUTO-IMMUNES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2012125893A1

  公开（公告）日：2012-09-20

  The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

  本发明提供了化合物I的公式及其药学上可接受的盐。公式I的化合物抑制JAK3的酪氨酸激酶活性，因此使它们在治疗炎症和自身免疫性疾病方面具有用途。
• TRICYCLIC PYRAZOL AMINE DERIVATIVES
  申请人：Gaillard Pascale

  公开号：US20120238545A1

  公开（公告）日：2012-09-20

  This invention relates to compounds of Formula (I*) as Pi3k inhibitors for treating autoimmune diseases, inflammatory disorders, multiple sclerosis and other diseases like cancers.

  本发明涉及式(I*)化合物，作为Pi3k抑制剂，用于治疗自身免疫性疾病、炎症性疾病、多发性硬化和其他疾病，如癌症。
• PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES
  申请人：Wrobleski Stephen T.

  公开号：US20140011800A1

  公开（公告）日：2014-01-09

  The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

  本发明提供了I型化合物及其药学上可接受的盐。式I化合物抑制JAK3的酪氨酸激酶活性，因此可用于治疗炎症和自身免疫性疾病。
• THIENO[3,2-C]PYRIDIN-4(5H)-ONES AS BET INHIBITORS
  申请人：GLAXOSMITHKLINE LLC

  公开号：US20160297832A1

  公开（公告）日：2016-10-13

  Thienopyridone compounds of formula (I): or a salt thereof, pharmaceutical compositions containing such compounds and their use in therapy, in particular in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.