1-(3-氨基甲基苄基)-4-哌啶醇 | 887588-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(3-氨基甲基苄基)-4-哌啶醇
• 英文名称: 1-(3-Aminomethylbenzyl)piperidin-4-ol
• 英文别名: 1-[[3-(aminomethyl)phenyl]methyl]piperidin-4-ol
• CAS: 887588-63-8
• 化学式: C₁₃H₂₀N₂O
• mdl: MFCD06656910
• 分子量: 220.31
• InChiKey: FZBAJTZKEDTSPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  49.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] ANTIBACTERIAL CHIRAL 8-(SUBSTITUTED PIPERIDINO)-BENZO [I, J] QUINOLIZINES, PROCESSES, COMPOSITIONS AND METHODS OF TREATMENT<br/>[FR] PIPERIDINO-BENZO [I, J] QUINOLIZINES A SUBSTITUTION DE PIPERIDINO EN 8 CHIRALES ANTIBACTERIENNES, PROCEDES, COMPOSITIONS ET METHODES DE TRAITEMENT
  申请人：SOUZA NOEL JOHN DE

  公开号：WO2001085728A2

  公开（公告）日：2001-11-15

  The present invention relates to optically pure 8-(substituted piperidino)-benzo [i,j] quinolizines, their isomers, derivatives, salts, pseudopolymorphs, polymorphs prodrugs and hydrates thereof, to processes for their preparation, and to pharmaceutical compositions comprising 8-(substituted piperidino)-benzo [i,j] quinolizines their isomers, derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions possess potent activity in treating local and systemic infections, particularly infections caused by sensitive and resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and nosocomial pathogens, and particularly those belonging to the staphylococcus, streptococcus and enterococcus groups. Methods for treating the diseases and disorders arising from the foregoing infections in humans and animals are described by administering the compounds of the invention to said humans and animals.