1-(4-羟基-2,2,6,6-四甲基哌啶-1-基)乙酮 | 63941-51-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(4-羟基-2,2,6,6-四甲基哌啶-1-基)乙酮
• 英文名称: 1-acetyl-2,2,6,6-tetramethyl-4-piperidinol
• 英文别名: 1-acetyl-2,2,6,6-tetramethyl-4-hydroxy-piperidine；1-acetyl-2,2,6,6-tetramethylpiperidin-4-ol；1-acetyl-4-hydroxy-2,2,6,6-tetramethylpiperidine；1-(4-Hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)ethan-1-one；1-(4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)ethanone
• CAS: 63941-51-5
• 化学式: C₁₁H₂₁NO₂
• 分子量: 199.293
• InChiKey: BYRAJSGSAYGRFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-羟基-2,2,6,6-四甲基哌啶-1-基)乙酮 在 三氟化硼乙醚 、 sodium hydroxide 作用下， 反应 1.1h， 生成 1-{2,2,6,6-Tetramethyl-4-[(oxiran-2-yl)methoxy]piperidin-1-yl}ethan-1-one
  参考文献：
  名称：

  一种含受阻胺基团的二元醇单体及其聚酯共 聚物

  摘要：

  本发明涉及一种含受阻胺基团的二元醇单体及其聚酯共聚物，二元醇单体是1‑取代基‑2,2,6,6‑四甲基‑4‑甘油醚基哌啶，其中取代基是甲基、乙基、乙酰基或者氧基；二元醇单体是由1‑取代基‑2,2,6,6‑四甲基‑4‑缩水甘油醚基哌啶在氢氧化钠水溶液中加热水解反应得到；聚酯共聚物是以对苯二甲酸或者或对苯二甲酸二甲酯、乙二醇和二元醇单体缩聚而成。本发明的优点在于：受阻胺基团连接在的聚酯主链上，与通用聚酯具有非常好的相容性，赋予聚酯良好的紫外光稳定性，同时保持聚酯优良的力学性能，同时，也具有优异的加工稳定性，加工过程中不产生刺激性气味。

  公开号：

  CN105085376B

文献信息

• Tetramethylpiperidino-s-triazines
  申请人：Ciba-Geigy Corporation

  公开号：US05059689A1

  公开（公告）日：1991-10-22

  Compounds which contain at least one group of the formula I ##STR1## in which X is a group which completes the ring to form a piperidine ring, are effective stabilizers for organic materials against damage by light, oxygen and heat.

  含有至少一个公式I（##STR1##）的化合物的化合物，其中X是一个使环闭合形成哌啶环的基团，是对有机材料具有光、氧和热稳定作用的有效的稳定剂。
• Piperidine derivatives, their production and use as stabilizers
  申请人：Sumitomo Chemical Co., Ltd.

  公开号：US04670488A1

  公开（公告）日：1987-06-02

  The present invention relates to a piperidine derivative represented by the general formula (I), ##STR1## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom or a C.sub.1 -C.sub.3 alkyl or C.sub.2 -C.sub.20 acyl group, R.sub.3 represents a hydrogen atom or a C.sub.1 -C.sub.20 alkyl, C.sub.6 -C.sub.20 aryl, C.sub.7 -C.sub.20 aralkyl or C.sub.2 -C.sub.20 acyl group, and l represents 1 to 3, and a stabilizer for organic substances containing said piperidine derivative as an effective ingredient.

  本发明涉及一种由通式（I）表示的哌啶衍生物，其中R.sub.1和R.sub.2独立地代表氢原子或C.sub.1-C.sub.3烷基或C.sub.2-C.sub.20酰基，R.sub.3代表氢原子或C.sub.1-C.sub.20烷基，C.sub.6-C.sub.20芳基，C.sub.7-C.sub.20芳基烷基或C.sub.2-C.sub.20酰基，l代表1至3，并且一种含有所述哌啶衍生物作为有效成分的有机物稳定剂。
• Peroxide free radical initiators containing hindered amine moieties with
  申请人：Ciba-Geigy Corporation

  公开号：US05051511A1

  公开（公告）日：1991-09-24

  Compounds which contain peroxide linkages as well as a hindered amine light stabilizer moiety of low basicity function as free radical polymerization initiators and provide a polymer containing a hindered amine stabilizer chemically bonded to said polymer. The low basicity of the instant compounds prevents interaction with acid catalysts used in some polymerization systems.

  含过氧化物键和受阻胺光稳定剂基团的化合物作为自由基聚合引发剂，能够提供一种聚合物，其中包含化学键合的受阻胺稳定剂。这些化合物的低碱性可以防止与某些聚合体系中使用的酸催化剂发生相互作用。
• Inhibition of pulp and paper yellowing using nitroxides, hydroxylamines and other coadditives
  申请人：——

  公开号：US20020124980A1

  公开（公告）日：2002-09-12

  Pulps or papers, especially chemimechanical or thermomechanical pulps or papers, which still contain lignin, have enhanced resistance to yellowing when they contain an effective stabilizing amount of a hindered amine compound which preferably is a nitroxide, a hydroxylamine or an ammonium salt thereof. This performance is often further enhanced by the presence of one or more coadditives selected from the group consisting of the UV absorbers, the polymeric inhibitors, the nitrones, the fluorescent whitening agents, metal chelating agents, sulfur containing stabilizers, metal salts and diene compounds. Combinations of nitroxides, hydroxylamines or their salts, benzotriazole or benzophenone UV absorbers and a metal chelating agent are particularly effective. Selected derivatives of 1-oxyl-2,2,6,6-tetramethyl-piperidin-4-ol and selected hydroxylamine salts are novel compounds and are surprisingly effective for this purpose.

  含有木质素的纸浆或纸张，特别是化学机械或热机械纸浆或纸张，如果它们含有有效的阻化胺化合物（最好是亚硝基自由基，羟胺或其铵盐），则具有增强的抗黄变性能。当与来自紫外线吸收剂、聚合抑制剂、亚硝基醇、荧光增白剂、金属螯合剂、含硫稳定剂、金属盐和二烯化合物等组成的一种或多种协同添加剂一起使用时，通常可以进一步提高其性能。亚硝基自由基、羟胺或其盐、苯并三唑或苯并酚类紫外线吸收剂和金属螯合剂的组合尤其有效。选择的1-氧基-2,2,6,6-四甲基哌啶-4-醇和选择的羟胺盐衍生物是新的化合物，出乎意料地有效。
• Fused-ring compounds and use thereof as drugs
  申请人：Hashimoto Hiromasa

  公开号：US20070032497A1

  公开（公告）日：2007-02-08

  The present invention provides a fused ring compound of the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a therapeutic agent for hepatitis C, which contains this compound. The compound of the present invention shows an anti-hapatitis C virus (HCV) action based on the HCV polymerase inhibitory activity, and is useful as a therapeutic agent or prophylactic agent for hepatitis C.

  本发明提供了以下式[I]的融合环化合物，其中每个符号如规范中定义的，其药学上可接受的盐以及包含该化合物的丙型肝炎治疗剂。本发明的化合物显示出基于丙型肝炎病毒（HCV）聚合酶抑制活性的抗HCV作用，并且可用作丙型肝炎的治疗剂或预防剂。