1-(4-苯基哌啶-4-基)乙醇 | 34361-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(4-苯基哌啶-4-基)乙醇
• 英文名称: 4-(α-Hydroxyaethyl)-4-phenylpiperidin
• 英文别名: 4-(α-Hydroxyethyl)-4-phenylpiperidin；1-(4-phenyl-piperidin-4-yl)-ethanol；α-methyl-4-phenylpiperidine-4-methanol；4-phenyl-4-piperidine ethanol；alpha-Methyl-4-phenylpiperidine-4-methanol；1-(4-phenylpiperidin-4-yl)ethanol
• CAS: 34361-19-8
• 化学式: C₁₃H₁₉NO
• 分子量: 205.3
• InChiKey: KZCXJZTWPDOBTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

文献信息

• TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Genentech, Inc.

  公开号：US20170226132A1

  公开（公告）日：2017-08-10

  Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
• TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Genentech, Inc.

  公开号：US20180086757A1

  公开（公告）日：2018-03-29

  Provided are triazolopyridine compounds that are inhibitors of JAK kinase, such as JAK1, compositions containing these compounds and methods for treating diseases mediated by a JAK kinase. In particular, provided are compounds of formula (I), stereoisomers, tautomers, solvates, prodrugs or pharmaceutically acceptable salts thereof, where R 1a , R 1b , R 1c , R 2 , R 3 , R 4 and R 5 are defined herein, pharmaceutical compositions comprising the compound and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, for example, for treating a disease or condition mediated by a JAK kinase in a patient.
• US4072686A
  申请人：——

  公开号：US4072686A

  公开（公告）日：1978-02-07
• US5019650A
  申请人：——

  公开号：US5019650A

  公开（公告）日：1991-05-28
• US9873709B2
  申请人：——

  公开号：US9873709B2

  公开（公告）日：2018-01-23