氟铝 | 21330-18-7

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 后过渡金属盐
• 中文名称: 氟铝
• 英文名称: Aluminum;fluoride
• CAS: 21330-18-7
• 化学式: AlF
• 分子量: 45.9799
• InChiKey: RSCDSAGMXGBEFR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.04
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  氟铝 、 以 aq. acetate buffer 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  Comparison of Al18F- and 68Ga-labeled NOTA-PEG4-LLP2A for PET imaging of very late antigen-4 in melanoma

  摘要：

  Malignant melanoma is an aggressive cancer with poor prognosis. Very late antigen-4 (VLA-4) is overexpressed in melanoma and many other tumors, making it an attractive target for developing molecular diagnostic and therapeutic agents. We compared (AlF)-F-18- and Ga-68-labeled LLP2A peptides for PET imaging of VLA-4 expression in melanoma. The peptidomimetic ligand LLP2A was modified with chelator 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (p-SCN-Bn-NOTA), and the resulting NOTA-PEG(4)-LLP2A peptide was then radiolabeled with (AlF)-F-18 or Ga-68. The two labeled peptides were assayed for in vitro and in vivo VLA-4 targeting efficiency. Good (AlF)-F-18 and Ga-68 radiolabeling yields were achieved, and the resulting PET tracers showed good serum stability. In the in vivo evaluation of the B16F10 xenograft mouse model, both tracers exhibited high accumulation with good contrast in static PET images. Compared with Ga-68-NOTA-PEG(4)-LLP2A, (AlF)-F-18-NOTA-PEG(4)-LLP2A resulted in relatively higher background, including higher liver uptake (1 h: 20.1 +/- 2.6 vs. 15.3 +/- 1.7%ID/g, P < 0.05; 2 h: 11.0 +/- 1.2 vs. 8.0 +/- 0.8%ID/g, P < 0.05) and lower tumor-to-blood ratios (2.5 +/- 0.4 vs. 3.3 +/- 0.5 at 1 h, P < 0.05; 5.1 +/- 0.9 vs. 7.3 +/- 0.6 at 2 h, P < 0.01) at some time points. The results obtained from the mice blocked with unlabeled peptides and VLA-4-negative A375 xenografts groups confirmed the high specificity of the developed tracers. Despite the relatively high liver uptake, both (AlF)-F-18-NOTA-PEG(4)-LLP2A and Ga-68-NOTA-PEG(4)-LLP2A exhibited high VLA-4 targeting efficacy with comparable in vivo performance, rendering them promising candidates for imaging tumors that overexpress VLA-4. Graphic abstract

  DOI：

  10.1007/s00775-019-01742-6
• 作为产物：
  描述：

  氟化铝 生成 氟铝
  参考文献：
  名称：

  GOLOTA, A. F.;BOGDANOV, S. N.;ZHURAVLEV, YU. F.;LIMANSKAYA, L. V.;SHESTAK+, IZV. AN CCCP. NEORGAN. MATER., 26,(1990) N1, S. 2389-2391

  摘要：

  DOI：

文献信息

• GOLOTA, A. F.;BOGDANOV, S. N.;ZHURAVLEV, YU. F.;LIMANSKAYA, L. V.;SHESTAK+, IZV. AN CCCP. NEORGAN. MATER., 26,(1990) N1, S. 2389-2391
  作者：GOLOTA, A. F.、BOGDANOV, S. N.、ZHURAVLEV, YU. F.、LIMANSKAYA, L. V.、SHESTAK+

  DOI：——

  日期：——
• Comparison of Al18F- and 68Ga-labeled NOTA-PEG4-LLP2A for PET imaging of very late antigen-4 in melanoma
  作者：Yongkang Gai、Lujie Yuan、Lingyi Sun、Huiling Li、Mengting Li、Hanyi Fang、Bouhari Altine、Qingyao Liu、Yongxue Zhang、Dexing Zeng、Xiaoli Lan

  DOI：10.1007/s00775-019-01742-6

  日期：2020.2

  Malignant melanoma is an aggressive cancer with poor prognosis. Very late antigen-4 (VLA-4) is overexpressed in melanoma and many other tumors, making it an attractive target for developing molecular diagnostic and therapeutic agents. We compared (AlF)-F-18- and Ga-68-labeled LLP2A peptides for PET imaging of VLA-4 expression in melanoma. The peptidomimetic ligand LLP2A was modified with chelator 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (p-SCN-Bn-NOTA), and the resulting NOTA-PEG(4)-LLP2A peptide was then radiolabeled with (AlF)-F-18 or Ga-68. The two labeled peptides were assayed for in vitro and in vivo VLA-4 targeting efficiency. Good (AlF)-F-18 and Ga-68 radiolabeling yields were achieved, and the resulting PET tracers showed good serum stability. In the in vivo evaluation of the B16F10 xenograft mouse model, both tracers exhibited high accumulation with good contrast in static PET images. Compared with Ga-68-NOTA-PEG(4)-LLP2A, (AlF)-F-18-NOTA-PEG(4)-LLP2A resulted in relatively higher background, including higher liver uptake (1 h: 20.1 +/- 2.6 vs. 15.3 +/- 1.7%ID/g, P < 0.05; 2 h: 11.0 +/- 1.2 vs. 8.0 +/- 0.8%ID/g, P < 0.05) and lower tumor-to-blood ratios (2.5 +/- 0.4 vs. 3.3 +/- 0.5 at 1 h, P < 0.05; 5.1 +/- 0.9 vs. 7.3 +/- 0.6 at 2 h, P < 0.01) at some time points. The results obtained from the mice blocked with unlabeled peptides and VLA-4-negative A375 xenografts groups confirmed the high specificity of the developed tracers. Despite the relatively high liver uptake, both (AlF)-F-18-NOTA-PEG(4)-LLP2A and Ga-68-NOTA-PEG(4)-LLP2A exhibited high VLA-4 targeting efficacy with comparable in vivo performance, rendering them promising candidates for imaging tumors that overexpress VLA-4. Graphic abstract