1-环己基-2-巯基咪唑 | 64038-58-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 中文名称: 1-环己基-2-巯基咪唑
• 英文名称: N-cyclohexylthioimidazole
• 英文别名: 1-cyclohexyl-1,3-dihydro-imidazole-2-thione；1-Cyclohexyl-1,3-dihydro-imidazol-2-thion；3-cyclohexyl-1H-imidazole-2-thione
• CAS: 64038-58-0
• 化学式: C₉H₁₄N₂S
• 分子量: 182.29
• InChiKey: OUOCKULYVNFTIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  18.8
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933290090

反应信息

• 作为反应物：
  描述：

  1-环己基-2-巯基咪唑 在 钾硼氢 作用下， 以 甲苯 为溶剂， 反应 168000.0h， 以91%的产率得到
  参考文献：
  名称：

  新型三（硫代咪唑基）硼酸酯配体及其锌配合物

  摘要：

  为了改善三（硫代咪唑基）硼酸盐配体配位的金属离子的包封，合成了四种具有邻取代苯基取代基的新配体以及具有对甲苯基和环己基取代基的配体。为了为其生物无机锌配合物化学提供基础，将它们转化为一些卤化锌、-羧酸盐、-硝酸盐、-苯酚盐和-苄酸盐配合物。它们形成高氯酸锌复合物，这是将醇和醇盐连接到锌上的生产性起始材料，从而为锌酶醇脱氢酶产生新的结构模型。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

  DOI：

  10.1002/ejic.200400994
• 作为产物：
  描述：

  3-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid methyl ester 在 sodium hydroxide 、 水 作用下， 生成 1-环己基-2-巯基咪唑
  参考文献：
  名称：

  Studies on Imidazoles. IV.¹ The Synthesis and Antithyroid Activity of Some 1-Substituted-2-mercaptoimidazoles

  摘要：

  DOI：

  10.1021/ja01180a036

文献信息

• Pharmaceutical Formulations comprising 1-substituted imidazoles, 1-substituted imidazoles and 1-substituted imidazoles for use in the treatment or prophylaxis of thrombo-embolic disorders
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0000951A1

  公开（公告）日：1979-03-07

  The invention relates to the use in medicine of 1-alkylimidazoles of formula in which A is a straight or branched, saturated or unsaturated acyclic hydrocarbon radical of from 1 to 3 carbon atoms; n is 0 or 1; and R is a cycloalkyl or cycloalkenyl radical of from 4 to 9 carbon atoms and optionally substituted by one, two, three or more alkyl radicals each containing from 1 to 4 carbon atoms, or, when n is 1, A and R together form an alkyl radical of from 4 to 7 carbon atoms or an alkenyl or alkynyl radical of from 4 to 9 carbon atoms, the imidazole being the free base or a pharmaceutically acceptable salt thereof. The 1-alkylimidazoles in which n is 0 and R ist cycloalkyl or cycloalkenyl are novel, as are those when A and R together form an alkenyl radical. Methods of preparing the 1-alkylimidazoles are disclosed. The 1-alkylimidazoles have pharmacological properties of use in medicine, in particular for the treatment or prophylaxis of thrombo-embolic disorders.

  本发明涉及式 1-烷基咪唑的医药用途。 其中 A 是 1 至 3 个碳原子的直链或支链、饱和或不饱和的无环烃基；n 是 0 或 1；和 R 是 4 至 9 个碳原子的环烷基或环烯烃基，并可选择被一个、两个、三个或多个烷基取代，每个烷基含有 1 至 4 个碳原子，或者，当 n 为 1 时，A 和 R 共同形成 4 至 7 个碳原子的烷基或 4 至 9 个碳原子的烯基或炔基，咪唑为游离基或其药学上可接受的盐。 n为0、R为环烷基或环烷烯基时的1-烷基咪唑是新颖的，A和R共同形成烯基时的1-烷基咪唑也是新颖的。 本发明公开了制备 1-烷基咪唑的方法。 1-烷基咪唑具有药理特性，可用于医药，特别是用于治疗或预防血栓栓塞性疾病。
• COMPOSITION FOR REMOVING AND PREVENTING FORMATION OF OXIDE ON THE SURFACE OF METAL WIRE
  申请人：LTC Co., Ltd.

  公开号：EP2878707A1

  公开（公告）日：2015-06-03

  The present invention proposes a method for removing an oxide formed on the surface of a copper film used in the process of manufacturing a circuit for a semiconductor, an organic light-emitting diode, an LED, or a liquid crystal display without causing corrosion on a lower metal film. The composition including corrosive amine may remove a metal oxide depending on the content of additive ranging from 0.01 to 10% regardless of the content of ultrapure water. A polar solvent other than the corrosive amine may efficiently remove an oxide from the surface of the metal when the same contains water and 0.01 to 20% of the additive.

  本发明提出了一种方法，用于去除在制造半导体、有机发光二极管、发光二极管或液晶显示器电路过程中使用的铜膜表面形成的氧化物，而不会对下层金属膜造成腐蚀。包括腐蚀性胺的组合物可以去除金属氧化物，具体取决于添加剂的含量，从 0.01%到 10%不等，与超纯水的含量无关。当含有水和 0.01%至 20%的添加剂时，腐蚀性胺以外的极性溶剂可有效去除金属表面的氧化物。
• One-Pot Preparation of 1-Substituted Imidazole-2-thione from Isothiocyanate and Amino Acetal
  作者：Koyo Matsuda、Isao Yanagisawa、Yasuo Isomura、Toshiyasu Mase、Tadao Shibanuma

  DOI：10.1080/00397919708007078

  日期：1997.10.1

  Isothiocyanates were treated with amino acetal and conc. HCl (0.5 eq.) successively in one-pot to afford 1-substituted imidazole-2-thiones in good yields.
• Preparation of 2-mercaptoimidazoles
  申请人：LILLY CO ELI

  公开号：US02585388A1

  公开（公告）日：1952-02-12
• Composition for Removing and Preventing Formation of Oxide on the Surface of Metal Wire
  申请人：LTC Co., Ltd.

  公开号：US20150299628A1

  公开（公告）日：2015-10-22

  The present invention proposes a method for removing an oxide formed on the surface of a copper film used in the process of manufacturing a circuit for a semiconductor, an organic light-emitting diode, an LED, or a liquid crystal display without causing corrosion on a lower metal film. The composition including corrosive amine may remove a metal oxide depending on the content of additive ranging from 0.01 to 10% regardless of the content of ultrapure water. A polar solvent other than the corrosive amine may efficiently remove an oxide from the surface of the metal when the same contains water and 0.01 to 20% of the additive.