(5S,7S)-2-hydroxy-1-methyl-2-azatricyclo[3.3.1.13,7]decane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (5S,7S)-2-hydroxy-1-methyl-2-azatricyclo[3.3.1.13,7]decane
• 化学式: C₁₀H₁₇NO
• 分子量: 167.25
• InChiKey: ORWXHNXGXZJPKA-DKEVHCRPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• TARGETED NITROXIDE AGENTS
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20200317730A1

  公开（公告）日：2020-10-08

  Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.