氨合二氯(环戊胺)铂(0) | 64538-66-5

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 中文名称: 氨合二氯(环戊胺)铂(0)
• 英文名称: cis-Pt(cyclopentylamine)(NH3)Cl2
• 英文别名: cis-Pt(NH3)(cyclopentylamine)Cl2；cis-Pt(NH3)(cpa)Cl2；Azane;cyclopentanamine;dichloroplatinum；azane;cyclopentanamine;dichloroplatinum
• CAS: 64538-66-5
• 化学式: C₅H₁₄Cl₂N₂Pt
• 分子量: 368.166
• InChiKey: OFISBMFZMPUEBF-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.94
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  氨合二氯(环戊胺)铂(0) 、 potassium iodide 以 丙酮 为溶剂， 反应 4.0h， 以97%的产率得到cis-[Pt(cyclopentylamine)(NH3)I2]
  参考文献：
  名称：

  双和三（羧基）铂（IV）复合物与混合氨基（间）配体在转位中表现出极高的细胞毒性

  摘要：

  合成了一系列具有反位氨基（间）氨酸配体的七个 diam（m）inebis（羧基）二羟基铂（IV）和 11 个 diam（m）inetris（羧基）羟基铂（IV）配合物，并通过多核 1H 表征， 13C、15N、195Pt NMR光谱。所有十八种物质的 IC50 值通过 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基-2H-溴化四唑 (MTT) 测定对三种人类癌细胞系进行测定。在顺铂敏感的 CH1(PA-1) 癌细胞中，diam(m)inebis(carboxylato)dihydroxidoplatinum(IV) 复合物在微摩尔范围内显示出 50% 的抑制浓度，而对于 diam(m)inetris(羧基）氢氧化铂（IV）系列，发现有希望的 IC50 值在纳摩尔范围内。

  DOI：

  10.1002/ejic.201403226
• 作为产物：
  描述：

  顺铂 、 环戊胺 在 盐酸 作用下， 以 水 为溶剂， 以74%的产率得到氨合二氯(环戊胺)铂(0)
  参考文献：
  名称：

  双和三（羧基）铂（IV）复合物与混合氨基（间）配体在转位中表现出极高的细胞毒性

  摘要：

  合成了一系列具有反位氨基（间）氨酸配体的七个 diam（m）inebis（羧基）二羟基铂（IV）和 11 个 diam（m）inetris（羧基）羟基铂（IV）配合物，并通过多核 1H 表征， 13C、15N、195Pt NMR光谱。所有十八种物质的 IC50 值通过 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基-2H-溴化四唑 (MTT) 测定对三种人类癌细胞系进行测定。在顺铂敏感的 CH1(PA-1) 癌细胞中，diam(m)inebis(carboxylato)dihydroxidoplatinum(IV) 复合物在微摩尔范围内显示出 50% 的抑制浓度，而对于 diam(m)inetris(羧基）氢氧化铂（IV）系列，发现有希望的 IC50 值在纳摩尔范围内。

  DOI：

  10.1002/ejic.201403226

文献信息

• Multinuclear magnetic resonance studies of the reactions of the antitumor complexes cis-Pt(L)2X2 and cis-Pt(NH3)(L)X2 (L=cyclobutylamine and cyclopentylamine) with guanosine and other bases and crystal structures of Pt(cyclopentylamine)2I2
  作者：Fernande D. Rochon、André L. Beauchamp、Chantal Dion

  DOI：10.1016/j.ica.2008.10.026

  日期：2009.8

  The crystal structures of two Pt(cyclopentylamine) I-2(2) compounds were determined by X-ray diffraction methods. Both crystals contain disordered cyclopentylamine ligands. Crystal I contains two independent trans-Pt(cyclopentylamine)(2)I-2 molecules and all the C atoms are disordered on two positions. The second crystal (II) is most interesting since it contains both cis- and trans-Pt(cyclopentylamine)(2)I-2 isomers in the same unit cell. It was prepared from the recrystallization of the cis isomer in acetone. The C atoms of the trans molecule in crystal II are disordered on two positions, while only one position was determined in the cis molecule, although some of the C thermal factors are quite high. The reactions of cis-Pt(amine)(2)X-2 and cis-Pt(NH3)(amine) X-2 (amine = cyclobutylamine and cyclopentylamine) with guanosine in water were studied in different Pt: guanosine proportions by multinuclear (H-1, Pt-195 and N-15) magnetic resonance spectroscopy. The presence of several species in solution was observed. For the mixed-cyclobutylamine compound, N-15 NMR has shown that some of the NH3 ligands have been displaced from the coordination sphere in the presence of an excess of guanosine. The reactions of the two mixed-ligand complexes cis-Pt(NH3)(amine) Cl-2 with 9-methylguanine, inosine and 9-methylhypoxanthine were also studied in water and the results are discussed. (C) 2008 Elsevier B. V. All rights reserved.