1-甲基哌啶-4-基1-苯基环戊羧酸酯盐酸(1:1) | 1952-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-甲基哌啶-4-基1-苯基环戊羧酸酯盐酸(1:1)
• 英文名称: 1-Methyl-4-piperidinyl 1-phenylcyclopentanecarboxylate hydrochloride
• 英文别名: (1-methylpiperidin-4-yl) 1-phenylcyclopentane-1-carboxylate;hydrochloride
• CAS: 1952-11-0
• 化学式: C18H26ClNO2
• 分子量: 323.9
• InChiKey: UPHKUNLWUBDUGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.56
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PARASYMPATHIKOMIMETIKUM UND PARASYMPATHIKOLYTIKUM ENTHALTENDES TTS
  申请人：LTS LOHMANN Therapie-Systeme AG

  公开号：EP0732924B1

  公开（公告）日：2009-06-10
• PHARMAZEUTISCHE FORMULIERUNG ZUR PROPHYLAXE BZW. VORBEHANDLUNG EINER VERGIFTUNG DURCH PHOSPHORORGANISCHE CHOLINESTERASEHEMMER
  申请人：LTS Lohmann Therapie-Systeme AG

  公开号：EP0732926B1

  公开（公告）日：2003-02-19
• Pharmaceutical formulation comprising a metaloporphyrin and method for its purification and use
  申请人：Bailey George S.

  公开号：US20080139524A1

  公开（公告）日：2008-06-12

  Pharmaceutical formulation for the prophylaxis, pretreatment and treatment of a poisoning caused by exposure to (either singly or as a mixture of agents) organophosphorus cholinesterase inhibitors, vesicating agents, polycyclic aromatic hydrocarbons, and aflatoxin B1. This invention is characterized by active substance comprised of a metaloporphyrin molecule with an associated metal moiety (Cu, Mg) of suitable purity and chemical composition to provide a bioavailable oral dosage form to attain predictable concentrations in target tissues and bodily fluids (plasma, bronchial secretions, etc.) sufficient to counteract the effects of toxic substances through chemical complexation or catalysis of toxin degradation. Although these metaloporphyrins are semisynthetic products of chlorophyll, the preferred starting material is chlorophyll a (Chla) extracted and purified from Spirulina pacifica or other sources. A specific method is invented to achieve a critical combination of purity and yield beyond those currently available.
• US5939095A
  申请人：——

  公开号：US5939095A

  公开（公告）日：1999-08-17
• US6114347A
  申请人：——

  公开号：US6114347A

  公开（公告）日：2000-09-05