1-苄基-4-(2-羟基苯基甲基)氨基哌啶 | 79098-92-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-苄基-4-(2-羟基苯基甲基)氨基哌啶
• 英文名称: 1-benzyl-4-(2-hydroxyphenylmethyl)aminopiperidine
• 英文别名: 2-(((1-benzylpiperidin-4-yl)amino)methyl)phenol；4-(2-hydroxybenzylamino)-1-benzylpiperidine；1-benzyl-4-[N-(o-hydroxybenzyl)-amino]-piperidine；2-[[(1-benzylpiperidin-4-yl)amino]methyl]phenol
• CAS: 79098-92-3
• 化学式: C₁₉H₂₄N₂O
• mdl: MFCD07310191
• 分子量: 296.412
• InChiKey: PEZATUMKVOFZTR-UHFFFAOYSA-N

物化性质

• 熔点：
  92.5-93.0 °C(Solv: ethanol (64-17-5))
• 沸点：
  441.6±45.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.368
• 拓扑面积：
  35.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-苄基-4-(2-羟基苯基甲基)氨基哌啶 生成 1-benzyl-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine
  参考文献：
  名称：

  TEHRANISI, MASAYUKI;OBASEH, XIROYUKI;TAKAI, XARUKI;KUBO, KADZUXIRO;KASUTA+

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(((1-benzylpiperidin-4-yl)imino)methyl)phenol 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 以76%的产率得到1-苄基-4-(2-羟基苯基甲基)氨基哌啶
  参考文献：
  名称：

  Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease

  摘要：

  The multitarget-directed strategy offers an effective and promising paradigm to treat the complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of N-benzylpiperidine analogs (17-31 and 32-46) were designed and synthesized as multi-functional inhibitors of acetyl cholinesterase (AChE) and beta-secretase-1 (BACE-1) with moderate to excellent inhibitory activities. Among the tested inhibitors, 25, 26, 40, and 41 presented the most significant and balanced inhibition against both the targets. Compounds 40 and 41 exhibited high brain permeability in the PAMPA-BBB assay, significant displacement of propidium iodide from the peripheral anionic site (PAS) of AChE, and were devoid of neurotoxicity towards SH-SY5Y neuroblastoma cell lines up to the maximum tested concentration of 80 mu M. Meanwhile, both these compounds inhibited self- and AChE-induced A beta aggregation in thioflavin T assay, which was also re-affirmed by morphological characterization of All aggregates using atomic force microscopy (AFM). Moreover, 40 and 41 ameliorated the scopolamine induced cognitive impairment in elevated plus and Y-maze experiments. Ex vivo and biochemical analysis established the brain AChE inhibitory potential and antioxidant properties of these compounds. Further, improvement in A beta(1-42)-induced cognitive impairment was also observed by compound 41 in the Morris water maze experiment with significant oral absorption characteristics ascertained by the pharmacokinetic studies. (C) 2019 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2019.02.030

文献信息

• Synthesis and pharmacological evaluation of piperidine derivatives with various heterocyclic rings at the 4-position.
  作者：HARUKI TAKAI、HIROYUKI OBASE、NOBUHIRO NAKAMIZO、MASAYUKI TERANISHI、KAZUHIRO KUBO、KATSUICHI SHUTO、TAMOTSU HASHIMOTO

  DOI：10.1248/cpb.33.1104

  日期：——

  A series of piperidine derivatives with various heterocyclic rings at the 4-position was prepared and tested for antihypertensive activity and other biological activities. The antihypertensive effects of the present compounds in the spontaneous hypertensive rat were less potent than those of previously reported compounds. However, among the compounds tested for antiulcer activity and antiinflammatory activity, some exhibited interesting properties.

  制备并在4-位具有各种杂环的一类哌啶衍生物，进行了抗高血压活性及其他生物活性的测试。本研究所合成的化合物在自发性高血压大鼠中的抗高血压效果不及先前报道的化合物。然而，在用于抗溃疡活性和抗炎活性测试的化合物中，一些展现出了有趣的特性。
• Piperidine derivatives
  申请人：Kyowa Hakko Kogyo Co., Ltd.

  公开号：US04344945A1

  公开（公告）日：1982-08-17

  New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.

  制备了具有有用药理活性（如降压活性）的新哌啶衍生物。
• Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them
  申请人：KYOWA HAKKO KOGYO CO., LTD

  公开号：EP0029707A1

  公开（公告）日：1981-06-03

  New piperidine derivatives which have a useful pharmacological activity such as a hypotensive activity are disclosed. The novel compounds are of the formula wherein A is hydroxy, halogen, lower alkyl, lower alkoxy, lower alkenyloxy, lower alkenyloxy, lower alkylthio, carboxy, lower alkoxycarbonyl, nitro, amino, lower alkylamino, lower alkanoylamino, sulfamoyl, mono- or di-lower alkylaminosulfonyl, lower alkylsulfonyl, carbamoyl, cyano or trifluoromethyl; m is 0 or an integer of 1-5, and when m is 2 or more, the A groups may be the same of different and any two A's may together form a lower alkylenedioxy group; X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R1 is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); R2 is hydrogen or lower alkyl; and Y is a monovalent or divalent group of the formula 1,2 or 3: wherein p and q are each 0 or 1 provided that p and q are not both 1 at the same time: and when p and q are both 0, B is -N=N-. p is 1 and q is 0, B is -CONH-, -COO-, and when p is 0 and q is 1, B is -CONH or -S02NH-; and R3 is hydroxy, lower alkoxy, halogen, trifluoromethyl, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, nitro or amino; n is 0 or an integer of 1-4, and when n is 2 or more, the R3 groups may be the same or different and any two R3 groups maytogetherform a lower alkylenedioxv group; wherein R3 and n are as defined above, and wherein R3 and n are as defined above. Also disclosed are acid addition salts of the above compounds, pharmaceutical compositions containing them and a method for their preparation.

  本研究公开了具有有用药理活性（如降血压活性）的新型哌啶衍生物。这些新型化合物的化学式为 其中 A 是羟基、卤素、低级烷基、低级烷氧基、低级烯氧基、低级烯酰氧基、低级烷硫基、羧基、低级烷氧羰基、硝基、氨基、低级烷基氨基、低级烷酰氨基、氨基磺酰基、单或双低级烷基氨基磺酰基、低级烷基磺酰基、氨基甲酰基、氰基或三氟甲基； m 为 0 或 1-5 的整数，当 m 为 2 或 2 个以上时，A 基团可以相同或不同，任意两个 A 基团可共同形成一个低级亚烷基二氧基基团； X 是氧、硫、羰基、羟甲基或亚甲基； R1 是具有 1-4 个碳原子的直链亚烷基，带有或不带有低级烷基取代基； R2 是氢或低级烷基；以及 Y 是式 1、2 或 3 的一价或二价基团： 其中 p 和 q 分别为 0 或 1，条件是 p 和 q 不能同时为 1：当 p 和 q 均为 0 时，B 为-N=N-。 当 p 和 q 均为 0 时，B 为-N=N-、 当 当 p 为 0 而 q 为 1 时，B 为-CONH 或-S02NH-； R3 是羟基、低级烷氧基、卤素、三氟甲基、三氟甲基、三氟甲氧基、三氟甲硫基、硝基或氨基； n 为 0 或 1-4 的整数，当 n 为 2 或更多时，R3 基团可以相同或不同，任意两个 R3 基团可共同构成一个低级亚烷基二氧基团； 其中 R3 和 n 如上文所定义，以及 其中 R3 和 n 如上定义。 还公开了上述化合物的酸加成盐、含有这些化合物的药物组合物及其制备方法。
• [EN] DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS<br/>[FR] INDUCTEURS, À BASE DE DIPHÉNYLBUTYLPIPÉRIDINE, DE L'AUTOPHAGIE
  申请人：HARVARD COLLEGE

  公开号：WO2011143444A3

  公开（公告）日：2012-04-05
• Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries
  作者：Stephen W. Kaldor、Miles G. Siegel、James E. Fritz、Bruce A. Dressman、Patric J. Hahn

  DOI：10.1016/0040-4039(96)01636-x

  日期：1996.9

  Solid supported nucleophiles and electrophiles are employed to expedite the work-up and purification of a variety of amine alkylations and acylations. These solid suported scavengers are particularly advantageous for the construction of non-peptide libraries in a parallel array format. Copyright (C) 1996 Elsevier Science Ltd