2,2'-[（1S，2S）-1,2-环己二基双[（E）-（亚硝基甲基亚炔）]]双[4-（叔丁基）-6-（4-哌啶基甲基）苯酚] | 919299-89-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 2,2'-[（1S，2S）-1,2-环己二基双[（E）-（亚硝基甲基亚炔）]]双[4-（叔丁基）-6-（4-哌啶基甲基）苯酚]
• 英文名称: (1S,2S)-N,N'-bis[3-(piperidinomethyl)-5-(tert-butyl) salicylidene] cyclohexane-1,2-diamine
• 英文别名: 2,2-((1S,2S)-1,2-Cyclohexanediylbis((e；4-tert-butyl-2-[[(1S,2S)-2-[[5-tert-butyl-2-hydroxy-3-(piperidin-1-ylmethyl)phenyl]methylideneamino]cyclohexyl]iminomethyl]-6-(piperidin-1-ylmethyl)phenol
• CAS: 919299-89-1
• 化学式: C₄₀H₆₀N₄O₂
• 分子量: 628.942
• InChiKey: QWZFCHMBYWXSLV-ZPGRZCPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  46
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  71.7
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  dichlorotetrakis(dimethylsulfoxide)ruthenium(II) 、 2,2'-[（1S，2S）-1,2-环己二基双[（E）-（亚硝基甲基亚炔）]]双[4-（叔丁基）-6-（4-哌啶基甲基）苯酚] 以 甲醇 为溶剂， 以76%的产率得到[Ru(DMSO)2((1S,2S)-N,N'-bis[2-piperidinomethyl)-5-(tert-butyl)salicylidene] cyclohexane-1,2-diamine)]
  参考文献：
  名称：

  Synthesis, characterization, DNA binding and cleavage studies of chiral Ru(II) salen complexes

  摘要：

  Interaction of chiral Ru(II) salen complexes (S)-1 and (R)-1 with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, CD measurements, thermal denaturation study and cleavage studies by agarose gel electrophoresis. The DNA binding affinity of (S)-1 (6.25 x 10(3) M-1) was found to be greater than (R)-1 (3.0 x 10(3) M-1). The antimicrobial studies of these complexes on five different gram (+)/(-) bacteria and three different fungal organisms showed selective inhibition of the growth of gram (+) bacteria and were not affective against gram (-) and fungal organisms. Further, the (S)-1 enantiomer inhibited the growth of organisms to a greater extent as compared to (R)-1 enantiomer. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2009.05.016

文献信息

• Synthesis, characterization, DNA binding and cleavage studies of chiral Ru(II) salen complexes
  作者：Noor-ul H. Khan、Nirali Pandya、Rukhsana I. Kureshy、Sayed H.R. Abdi、Santosh Agrawal、Hari C. Bajaj、Jagruti Pandya、Akashya Gupte

  DOI：10.1016/j.saa.2009.05.016

  日期：2009.9

  Interaction of chiral Ru(II) salen complexes (S)-1 and (R)-1 with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, CD measurements, thermal denaturation study and cleavage studies by agarose gel electrophoresis. The DNA binding affinity of (S)-1 (6.25 x 10(3) M-1) was found to be greater than (R)-1 (3.0 x 10(3) M-1). The antimicrobial studies of these complexes on five different gram (+)/(-) bacteria and three different fungal organisms showed selective inhibition of the growth of gram (+) bacteria and were not affective against gram (-) and fungal organisms. Further, the (S)-1 enantiomer inhibited the growth of organisms to a greater extent as compared to (R)-1 enantiomer. (C) 2009 Elsevier B.V. All rights reserved.