氯化镁单水合物

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属盐
• 中文名称: 氯化镁单水合物
• 英文名称: magnesium;dichloride;hydrate
• 化学式: Cl2H2MgO
• 分子量: 113.22
• InChiKey: MJMDTFNVECGTEM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -7.2
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  氯化钠 、 氯化钾 、 Calcium chloride, monohydrate 、 氯化镁单水合物 、 sodium acetate 以 溶剂黄146 、 水 为溶剂， 生成 sodium acetate acetic acid
  参考文献：
  名称：

  SOLID DIALYSIS A AGENT CONTAINING ALKALI METAL DIACETATE, AND TWO-PART TYPE LOW-ACETATE DIALYSIS AGENT USING SAME

  摘要：

  [问题] 提供一种用于制备碳酸盐透析液的固态透析A剂，该剂能够使透析液中的总乙酸盐含量低，并且具有葡萄糖等成分的良好储存稳定性和减少乙酸气味。 [解决方案] 一种用于制备碳酸盐透析液的固态透析A剂，其中：固态透析A剂包含葡萄糖、乙酸和乙酸盐；乙酸与乙酸盐的混合物中至少一部分为碱金属二乙酸盐；并且乙酸/乙酸盐摩尔比调整为1/0.5至1/2。这种固态透析A剂可以制备出总乙酸盐浓度为2至小于6 mEq/L的碳酸盐透析液。此外，透析A剂具有成分的良好稳定性和减少乙酸气味。

  公开号：

  US20160235785A1

文献信息

• Local anesthetic compounds
  申请人：Advanced Medicine, Inc.

  公开号：US06355637B1

  公开（公告）日：2002-03-12

  This invention provides novel quinazolinone compounds and pharmaceutically acceptable salts thereof, which are useful as local anesthetics. This invention also provides pharmaceutical compositions containing such compounds; methods for producing local anesthesia in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

  本发明提供了新型喹唑啉酮化合物及其药学上可接受的盐，其可用作局部麻醉剂。本发明还提供包含这样的化合物的制药组合物；使用这样的化合物在哺乳动物中产生局部麻醉的方法；以及用于制备这样的化合物的过程和中间体。
• NOVEL N-ACETYLGLUCOSAMINE-2-EPIMERASE AND METHOD FOR PRODUCING CMP-NEURAMINIC ACID USING THE SAME
  申请人：Woo Jin Suk

  公开号：US20110287488A1

  公开（公告）日：2011-11-24

  The present invention relates to a novel N-acetylglucosamine-2-epimerase and a method for preparing CMP-N-acetylneuraminic acid, more specifically, relates to a N-acetylglucosamine-2-epimerase derived from Bacteroides fragilis NCTC 9343, and a method for preparing CMP-N-acetylneuraminic acid using said N-acetylglucosamine-2-epimerase. According to the present invention, CMP-N-acetylneuraminic acid can be produced economically in a large amount through a one-step reaction using cytidine monophosphate and N-acetyl-D-glucosamine which are inexpensive substrates.

  本发明涉及一种新型的N-乙酰葡萄糖胺-2-表皮酶和制备CMP-N-乙酰神经酰胺酸的方法，更具体地，涉及一种源自Bacteroides fragilis NCTC 9343的N-乙酰葡萄糖胺-2-表皮酶，以及使用该N-乙酰葡萄糖胺-2-表皮酶制备CMP-N-乙酰神经酰胺酸的方法。根据本发明，可以通过使用廉价的底物胞苷酸单磷酸和N-乙酰-D-葡萄糖胺进行一步反应，经济地大量生产CMP-N-乙酰神经酰胺酸。
• N-acetylglucosamine-2-epimerase and method for producing CMP-neuraminic acid using the same
  申请人：Woo Jin Suk

  公开号：US08852891B2

  公开（公告）日：2014-10-07

  The present invention relates to a novel N-acetylglucosamine-2-epimerase and a method for preparing CMP-N-acetylneuraminic acid, more specifically, relates to a N-acetylglucosamine-2-epimerase derived from Bacteroides fragilis NCTC 9343, and a method for preparing CMP-N-acetylneuraminic acid using said N-acetylglucosamine-2-epimerase. According to the present invention, CMP-N-acetylneuraminic acid can be produced economically in a large amount through a one-step reaction using cytidine monophosphate and N-acetyl-D-glucosamine which are inexpensive substrates.

  本发明涉及一种新型N-乙酰葡萄糖胺-2-表皮酶及其制备CMP-N-乙酰神经酰胺酸的方法，更具体地，涉及一种来源于Bacteroides fragilis NCTC 9343的N-乙酰葡萄糖胺-2-表皮酶，以及使用该N-乙酰葡萄糖胺-2-表皮酶制备CMP-N-乙酰神经酰胺酸的方法。根据本发明，可以通过使用价格便宜的细胞嘧啶单磷酸和N-乙酰-D-葡萄糖胺这两种底物进行一步反应，经济地大量生产CMP-N-乙酰神经酰胺酸。
• DIALYSIS AGENT A CONTAINING ACETIC ACID AND ACETATE SALT, AND A TWO-PART DIALYSIS AGENT USING THEREOF
  申请人：Tomita Pharmaceutical Co., Ltd.,

  公开号：US20140097386A1

  公开（公告）日：2014-04-10

  The purpose of the present invention is to provide a dialysis agent A, which is able to set the total acetate ion content in the dialysate to a low value, excellent in storage stability of glucose, able to reduce the acetic acid odor, and able to suppress the corrosion of the dialysate delivery system and the dialysis machine, as well as to provide a two pack type dialysis agent utilizing the dialysis agent A. In the dialysis agent A used in the preparation of a bicarbonate dialysate, which is used as one part of a two pack type dialysis agent, it becomes possible to prepare a bicarbonate dialysate having the total acetate ion concentration of between 2 mEq/L or more and less than 6 mEq/L by allowing to include glucose, acetic acid and acetate salt and to satisfy the molar ratio of 1:0.5 to 2 of acetic acid and acetate salt, and include acetic acid and acetate salt in a total amount of between 2 mEq or more and less than 6 mEq in the dialysis agent A required to prepare 1 L of the bicarbonate dialysate. Moreover, according to the dialysis agent A, in addition to the excellent stability of glucose, it is possible to reduce the acetic acid odor, and furthermore possible to suppress the corrosion of the dialysate delivery system and the dialysis machine.

  本发明的目的是提供一种透析剂A，能够将透析液中的总乙酸离子含量设置为低值，具有优异的葡萄糖储存稳定性，能够减少乙酸气味，并能够抑制透析液输送系统和透析机的腐蚀，同时提供一种利用透析剂A的两包装型透析剂。在制备用作两包装型透析剂的一部分的碳酸氢盐透析液中使用的透析剂A中，通过包含葡萄糖，乙酸和乙酸盐，并满足乙酸和乙酸盐的1:0.5到2的摩尔比，以及在所需制备1L碳酸氢盐透析液的透析剂A中包含2mEq或更多但小于6mEq的乙酸和乙酸盐的总量，就可以制备出总乙酸离子浓度在2mEq/L或更高但小于6mEq/L的碳酸氢盐透析液。此外，根据透析剂A，除了具有优异的葡萄糖稳定性外，还可以减少乙酸气味，并进一步抑制透析液输送系统和透析机的腐蚀。
• SOLID DIALYSIS A AGENT CONTAINING ALKALI METAL DIACETATE, AND TWO-PART TYPE LOW-ACETATE DIALYSIS AGENT USING SAME
  申请人：TOMITA PHARMACEUTICAL CO., LTD.

  公开号：US20160235785A1

  公开（公告）日：2016-08-18

  [Problem] To provide a solid dialysis A agent which is to be used in preparing a bicarbonate dialysis fluid, which enables the setting of a low total acetate ion content in a dialysis fluid, and which exhibits excellent storage stability of glucose or the like and a reduced acetic acid odor. [Solution] A solid dialysis A agent which is to be used in preparing a bicarbonate dialysis fluid, wherein: the solid dialysis A agent contains glucose, acetic acid and an acetate salt; at least a part of a mixture of the acetic acid with the acetate salt is an alkali metal diacetate; and the acetic acid/acetate salt molar ratio is adjusted to 1/0.5 to 1/2. This solid dialysis A agent makes it possible to prepare a bicarbonate dialysis fluid which has a total acetate ion concentration of 2 to less than 6 mEq/L. Further, the dialysis A agent exhibits excellent stability of ingredients and a reduced acetic acid odor.

  [问题] 提供一种用于制备碳酸盐透析液的固态透析A剂，该剂能够使透析液中的总乙酸盐含量低，并且具有葡萄糖等成分的良好储存稳定性和减少乙酸气味。 [解决方案] 一种用于制备碳酸盐透析液的固态透析A剂，其中：固态透析A剂包含葡萄糖、乙酸和乙酸盐；乙酸与乙酸盐的混合物中至少一部分为碱金属二乙酸盐；并且乙酸/乙酸盐摩尔比调整为1/0.5至1/2。这种固态透析A剂可以制备出总乙酸盐浓度为2至小于6 mEq/L的碳酸盐透析液。此外，透析A剂具有成分的良好稳定性和减少乙酸气味。