2-(1-甲基哌啶-2-基)乙腈 | 106825-82-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 2-(1-甲基哌啶-2-基)乙腈
• 英文名称: 2-cyanomethyl-1-methylpiperidine
• 英文别名: 1-Methyl-2-piperidineacetonitrile；2-(1-methylpiperidin-2-yl)acetonitrile
• CAS: 106825-82-5
• 化学式: C₈H₁₄N₂
• 分子量: 138.213
• InChiKey: JIHBUFRAYUUZBS-UHFFFAOYSA-N

物化性质

• 沸点：
  77-78 °C(Press: 0.2 Torr)
• 密度：
  0.930±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1-甲基哌啶-2-基)乙腈 以70的产率得到(1-甲基-哌啶-2-基)-乙酸
  参考文献：
  名称：

  Journal of Labelled Compounds and Radiopharmaceuticals. 2010, 23, 749-760

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(2-氯甲基)-n-甲基哌啶盐酸盐 以81的产率得到2-(1-甲基哌啶-2-基)乙腈
  参考文献：
  名称：

  Journal of Labelled Compounds and Radiopharmaceuticals. 2010, 23, 749-760

  摘要：

  DOI：

文献信息

• Pyrrolopyrimidine Derivatives Substituted with Cyclic Amino Group
  申请人：NAKAZATO Atsuro

  公开号：US20080287397A1

  公开（公告）日：2008-11-20

  An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. This problem can be solved with a pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by formula [I] below which has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  本发明的目的是提供一种CRF受体拮抗剂，作为治疗或预防与CRF有关的疾病的药物，例如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃病、药物依赖、癫痫、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、皮炎、精神分裂症等。这个问题可以通过下式[I]所表示的带有环状氨基基团的吡咯吡嘧啶或吡咯吡啶衍生物来解决，其具有高亲和力，对CRF受体有效，并且对与CRF有关的疾病也有效。
• PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH CYCLIC AMINO GROUP
  申请人：NAKAZATO Atsuro

  公开号：US20110130364A1

  公开（公告）日：2011-06-02

  An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. This problem can be solved with a pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by formula [I] below which has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  本发明的目的是提供一种CRF受体拮抗剂，该拮抗剂作为治疗或预防CRF参与的疾病的药物，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃病、药物依赖、癫痫、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、皮炎、精神分裂症等方面有效。这个问题可以通过一种代表式[I]下的带有环状氨基基团的吡咯吡咪啉或吡咯吡啶衍生物来解决，该衍生物对CRF受体具有高亲和力，并对CRF参与的疾病有效。
• Synthesis of 2-Cyanomethyl-1-Methylpiperidine
  作者：Niranjan M. Deo、Peter A. Crooks

  DOI：10.1080/00397919508011406

  日期：1995.3

  An improved method for the synthesis of 2-cyanomethyl-1-methylpiperidine is reported.
• Dco Niranjan M., Crooks Peter A., Synth. Commun, 25 (1995) N 5, S 691-701
  作者：Dco Niranjan M., Crooks Peter A.

  DOI：——

  日期：——
• MOHAMMAD T.; MIDHA K. K.; HAWES E. M., J. LABELLED COMPOUNDS AND RADIOPHARM., 23,(1986) N 7, 749-760
  作者：MOHAMMAD T.、 MIDHA K. K.、 HAWES E. M.

  DOI：——

  日期：——