2-(1-苄基-2-哌啶基)乙胺 | 915919-74-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 2-(1-苄基-2-哌啶基)乙胺
• 英文名称: 2-(1-benzylpiperidin-2-yl)ethan-1-amine
• 英文别名: 2-(1-Benzylpiperidin-2-YL)ethanamine
• CAS: 915919-74-3
• 化学式: C₁₄H₂₂N₂
• 分子量: 218.342
• InChiKey: KDPMGDIOCGIION-UHFFFAOYSA-N

物化性质

• 沸点：
  319.4±15.0 °C(Predicted)
• 密度：
  1.005±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  4-[6-氨基-8-羟基-2-(2-甲氧基乙氧基)嘌呤-9-基甲基]苯甲酸 、 2-(1-苄基-2-哌啶基)乙胺 在 N,N-二异丙基乙胺 、 ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 4.0h， 生成 4-((6-amino-8-hydroxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)-N-(2-(1-benzylpiperidin-2-yl)ethyl)benzamide
  参考文献：
  名称：

  [EN] TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS
  [FR] AGONISTES DE TLR7/8 ET COMPOSITIONS LIPOSOMALES

  摘要：

  本公开涉及一种利用远程加载的方法将调节剂（TLR）7/8激动剂装载到脂质体中，以及适用于通过该方法将TLR7/8激动剂装载到脂质体的部件套件。本公开进一步涉及包含TLR7/8激动剂盐的脂质体，并且利用该脂质体用于刺激免疫反应和/或治疗临床疾病。最后，本公开涉及一种适合远程装载到脂质体中的TLR7/8激动剂。

  公开号：

  WO2020023680A1

文献信息

• Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors
  申请人：Wentzler Sylvie

  公开号：US20070093480A1

  公开（公告）日：2007-04-26

  Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.

  化合物的新颖结构如下（I）：或其药学上可接受的盐，其中R、R1、R2、R3、R4、R5和R6的含义如描述中所述，包括所述化合物的药物组合物以及将其用作蛋白激酶抑制剂的用途。
• Piperidine and piperazine compounds for use in the treatment of Alzheimer
  申请人：Eisai Co., Ltd.

  公开号：EP1116716A1

  公开（公告）日：2001-07-18

  A cyclic amine compound or a salt thereof is defined by the formula: in which J is (a) an optionally substituted group selected from (1) phenyl, (2) pyridyl, (3) pyrazyl, (4) quinolyl, (5) cyclohexyl, (6) quinoxalyl and (7) furyl; (b) a monovalent or divalent group, in which the phenyl may have a substituent(s) selected from the group consisting of (1) indanyl, (2) indanonyl, (3) indenyl, (4) indenonyl, (5) indanedionyl, (6) tetralonyl, (7) benzosuberonyl, (8) indanolyl and (9) C6H5-CO-CH(CH3)-; (c) a monovalent group derived from a cyclic amide compound; (d) a lower alkyl; or (e) a group of R21-CH=CH- in which R21 is hydrogen or a lower alkoxycarbonyl; B is a bridging group; T is a nitrogen; Q is nitrogen, carbon or >N→0; q is an integer of 1 to 3; K is hydrogen, an optionally substituted phenyl group, an arylalkyl in which the phenyl may have a substituent, cynnamyl, a lower alkyl, pyridylmethyl, a cycloalkylalkyl, adamantanemethyl, furylmethyl, a cycloalkyl, a lower alkoxycarbonyl or an acyl; and ----¯ shows a single bond or a double bond. The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.

  一个环状胺化合物或其盐的定义公式为：其中J是(a) 选择自(1) 苯基，(2) 吡啶基，(3) 吡唑基，(4) 喹啉基，(5) 环己基，(6) 喹噁啉基和(7) 呋喃基的可选取代基；(b) 一价或二价基团，其中苯基可以具有选自(1) 吲哚基，(2) 吲哚基丙烷基，(3) 茚基，(4) 茚基丙烷基，(5) 吲哚二酮基，(6) 四酮基，(7) 苯并戊二酰基，(8) 吲哚醇基和(9) C6H5-CO-CH(CH3)-的取代基；(c) 源自环状酰胺化合物的一价基团；(d) 较低的烷基；或(e) R21-CH=CH-中R21是氢或较低的烷氧羰基的基团；B是桥接基团；T是氮；Q是氮、碳或>N→0；q是1到3的整数；K是氢、可选取代苯基、芳基烷基，其中苯基可以具有取代基，肉桂酸基，较低的烷基，吡啶甲基，环状烷基烷基，金刚烷基甲基，呋喃基甲基，环状烷基，较低的烷氧羰基或酰基；而----¯表示单键或双键。该化合物用于制备药物组合物和用于治疗老年痴呆症的药物。
• 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease
  申请人：Eisai Co., Ltd.

  公开号：EP0296560A2

  公开（公告）日：1988-12-28

  A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, = (CH-CH = CH)b-, = CH-(CH2)c- or = (CH-CH)d = and the ring including T and Q is piperidine. The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.

  环胺化合物的定义如式所示： 其中 J 是茚基、茚壬基、茚基、茚烯基、茚二壬基、四壬基、苯并琥珀酰基、 茚醇基或其二价基团，K 是苯基、B是-(CHR22)r-，R22是H或甲基、-CO-(CHR22)r-、＝(CH-CH＝CH)b-、＝CH-(CH2)c-或＝(CH-CH)d＝，包括T和Q的环是哌啶。该化合物可用于制备药物组合物和对老年痴呆症有效的药物。
• Cyclic amide derivatives
  申请人：Eisai Co., Ltd.

  公开号：EP0468187A2

  公开（公告）日：1992-01-29

  The cyclic amide derivative is defined by the formula (I) or a salt thereof: R1-(CH2)n-Z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an integer of 1 to 10 and Z is R2 being an aryl, a substituted aryl, a cycloalkyl or a heterocyclic group, m being an integer of 1 to 6, R3 being hydrogen or a lower alkyl, R4 being an aryl or a substituted aryl, a cycloalkyl or a heterocyclic group, p being an integer of 1 to 6, provided that the cyclic amide compound is quinazoline-on or quinazoline-dion, R2 and R4 are neither aryl nor substituted aryl. The cyclic amide compound is pharmacologically effective to prevent and treat diseases due to insufficiency of the central choline functions.

  环酰胺衍生物由式 (I) 或其盐定义 或其盐：R1-(CH2)n-Z 其中 R1 是由环酰胺化合物衍生的基团，可取代或未取代，n 是零或 1 至 10 的整数，Z 是 R2 是芳基、取代的芳基、环烷基或杂环基，m 是 1 至 6 的整数，R3 是氢或低级烷基，R4 是芳基或取代的芳基、环烷基或杂环基，p 是 1 至 6 的整数，条件是环酰胺化合物是喹唑啉酮或喹唑啉二酮，R2 和 R4 既不是芳基也不是取代的芳基。环酰胺化合物对预防和治疗中枢胆碱功能不足引起的疾病具有药理作用。
• 4-[2-indanyl-1-one]alkylpiperidines as anticholinergic agents
  申请人：Eisai Co., Ltd.

  公开号：EP0673927A1

  公开（公告）日：1995-09-27

  A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-(CH2)c- or =(CH-CH)d= and the ring including T and Q is piperidine. The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.

  环胺化合物的定义如下式所示 其中 J 是茚基、茚壬基、茚基、茚烯基、茚二壬基、四壬基、苯并琥珀酰基、 茚醇基或其二价基团，K 是苯基、B是-(CHR22)r-，R22是H或甲基、-CO-(CHR22)r-、=(CH-CH=CH)b-、=CH-(CH2)c-或=(CH-CH)d=，包括T和Q的环是哌啶。该化合物可用于制备药物组合物和对老年痴呆症有效的药物。