N-(1-butylbutyl)-1,5-dideoxy-1,5-imino-D-glucitol | 211987-36-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(1-butylbutyl)-1,5-dideoxy-1,5-imino-D-glucitol
• 英文别名: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-octan-4-ylpiperidine-3,4,5-triol
• CAS: 211987-36-9
• 化学式: C₁₄H₂₉NO₄
• 分子量: 275.389
• InChiKey: HKOKFWKDTXFLHY-ZLMOABSSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  84.2
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
  申请人：Mueller A. Richard

  公开号：US20050119310A1

  公开（公告）日：2005-06-02

  Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.

  提供了一种治疗哺乳动物，尤其是人类肝炎病毒感染的方法和组合物。该方法包括（1）单独或与核苷类抗病毒药物、核苷酸类抗病毒药物、二者的混合物或免疫调节/免疫刺激剂结合使用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或（2）单独或与核苷类抗病毒药物、核苷酸类抗病毒药物、或二者的混合物以及免疫调节/免疫刺激剂结合使用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。
• Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
  申请人：Mueller A. Richard

  公开号：US20050267153A1

  公开（公告）日：2005-12-01

  Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.

  提供了用于治疗哺乳动物，尤其是人类乙型肝炎病毒感染的方法和组合物。该方法包括（1）单独或与核苷类抗病毒药物、核苷酸类抗病毒药物、它们的混合物或免疫调节/免疫刺激剂结合使用N-取代-1,5-二脱氧-1,5-亚胺-D-葡萄糖醇化合物，或（2）单独或与核苷类抗病毒药物、核苷酸类抗病毒药物或它们的混合物以及免疫调节/免疫刺激剂结合使用N-取代-1,5-二脱氧-1,5-亚胺-D-葡萄糖醇化合物。
• USE OF N-SUBSTITUTED-1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL COMPOUNDS IN COMBINATION THERAPY FOR TREATING HEPATITIS VIRUS INFECTIONS
  申请人：——

  公开号：US20030100532A1

  公开（公告）日：2003-05-29

  Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

  提供了一种治疗哺乳动物，特别是人类肝炎病毒感染的方法和组合物。该方法包括(1)与核苷类抗病毒药物、核苷酸类抗病毒药物、两者的混合物或免疫调节/免疫刺激剂结合使用N-取代-1,5-二去氧-1,5-亚胺-D-葡萄糖醇化合物，或(2)与核苷类抗病毒药物、核苷酸类抗病毒药物、或两者的混合物以及免疫调节/免疫刺激剂结合使用N-取代-1,5-二去氧-1,5-亚胺-D-葡萄糖醇化合物。
• Liposome treatment of viral infections
  申请人：University of Oxford

  公开号：EP2356990A2

  公开（公告）日：2011-08-17

  One can treat a viral infection such as hepatitis B (HBV), hepatitis C (HCV), and bovine viral diarrhea virus (BVDV) infections via the delivery of pH sensitive liposomes directly into the endoplasmic reticulum (ER) membrane. Two exemplary liposome formulations are DOPE/CHEMS (DC liposomes) and DOPE/CHEMS/PEG-PE (DCPP liposomes). DC and DCPP liposomes can optimize the intracellular delivery of N-butyl deoxynojirimycin (NB-DNJ), and consequently increase the in vivo activity of this iminosugar several orders of magnitude, and could be used in combination with other therapeutic agents such as interferon and/or ribavirin. The optimized release of NB-DNJ directly into the ER can be also applied for the treatment of other viruses, for which NB-DNJ is known to be an effective antiviral, such as human immunodeficiency virus (HIV).

  人们可以通过将 pH 值敏感的脂质体直接输送到内质网（ER）膜来治疗病毒感染，如乙型肝炎（HBV）、丙型肝炎（HCV）和牛病毒性腹泻病毒（BVDV）感染。两种典型的脂质体制剂是 DOPE/CHEMS（DC 脂质体）和 DOPE/CHEMS/PEG-PE（DCPP 脂质体）。DC 和 DCPP 脂质体可优化 N-丁基脱氧野尻霉素（NB-DNJ）的细胞内递送，从而将这种亚氨基糖的体内活性提高几个数量级，并可与干扰素和/或利巴韦林等其他治疗剂结合使用。经过优化的 NB-DNJ 直接释放到 ER 中的方法也可用于治疗其他病毒，已知 NB-DNJ 是一种有效的抗病毒药物，如人类免疫缺陷病毒（HIV）。
• Methods of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D- glucuitol compounds in combination therapy
  申请人：Jacob S. Gary

  公开号：US20060106065A1

  公开（公告）日：2006-05-18

  Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

  本发明提供了治疗哺乳动物，特别是人类肝炎病毒感染的方法和组合物。这些方法包括：(1) 将 N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物与核苷类抗病毒剂、核苷酸类抗病毒剂、其混合物或免疫调节/免疫刺激剂联合使用、或 (2) 将 N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物与核苷类抗病毒剂、核苷酸类抗病毒剂或其混合物以及免疫调节/免疫刺激剂结合使用。