1-{(2R)-2-[N-((2E)-5-amino-5-methylhex-2-enoyl)-N-methylamino]-3-(biphenyl-4-yl)propionyl}4-benzylpiperidine-4-carboxylic acid methylamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-{(2R)-2-[N-((2E)-5-amino-5-methylhex-2-enoyl)-N-methylamino]-3-(biphenyl-4-yl)propionyl}4-benzylpiperidine-4-carboxylic acid methylamide
• 英文别名: 1-{(1R)-2-[N-((2E)-5-amino-3,5-dimethylhex-2-enoyl)-N-methylamino]-3-(2-naphthyl)propionyl)-4-benzylpiperidine-4-carboxylic acid methylamide；1-{(2R)-2-[N-((2E)-5-amino-3,5-dimethylhex-2-enoyl)-N-methylamino]-3-(2-naphthyl)propionyl}-4-benzylpiperidine-4-carboxylic acid methylamide；1-[(2R)-2-[[(E)-5-amino-3,5-dimethylhex-2-enoyl]-methylamino]-3-naphthalen-2-ylpropanoyl]-4-benzyl-N-methylpiperidine-4-carboxamide
• 化学式: C₃₆H₄₆N₄O₃
• 分子量: 582.786
• InChiKey: KLXKPSDGVAUHRE-ZBZAXRJPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  43
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  95.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES
  申请人：NOVO NORDISK A/S

  公开号：EP1077941B1

  公开（公告）日：2009-08-12
• Method of treating cell proliferative disorders using growth hormone secretagogues
  申请人：Polvino William J.

  公开号：US20080207640A1

  公开（公告）日：2008-08-28

  The present invention relates to a method of treating cell proliferative disorders by administering to a subject an effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof.
• Methods of treating emesis using growth hormone secretagogues
  申请人：Mann William R.

  公开号：US20080300194A1

  公开（公告）日：2008-12-04

  The present invention relates to methods of treating or preventing emesis and improving a subject's ASAS score by administering to the subject an effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof.
• Method of Stimulating the Motility of the Gastrointestinal System Using Growth Hormone Secretagogues
  申请人：Polvino William J.

  公开号：US20100087381A1

  公开（公告）日：2010-04-08

  The present invention relates to a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders or diseases) of the gastrointestinal system. The method comprises administering to a subject in need thereof a therapeutically effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof. The growth hormone secretagogue can be co-administered with a laxative, a H 2 receptor antagonist, a serotonin 5-HT 4 agonist, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.
• Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues
  申请人：Polvino William J.

  公开号：US20120077745A1

  公开（公告）日：2012-03-29

  The present invention relates to a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders or diseases) of the gastrointestinal system. The method comprises administering to a subject in need thereof a therapeutically effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof. The growth hormone secretagogue can be co-administered with a laxative, a H 2 receptor antagonist, a serotonin 5-HT 4 agonist, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.