1-Benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid
• 化学式: C₁₉H₁₈FNO₃
• 分子量: 327.3
• InChiKey: HUQNFMZOWOEJEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PROCESS FOR PRODUCING 4-ARYLPIPERIDINE-3-CARBINOLS AND RELATED COMPOUNDS
  申请人：Synthon B.V.

  公开号：EP1124802A1

  公开（公告）日：2001-08-22
• [EN] PROCESS FOR PRODUCING 4-ARYLPIPERIDINE-3-CARBINOLS AND RELATED COMPOUNDS<br/>[FR] PROCEDE DE PRODUCTION DE 4-ARYLPIPERIDINE-3-CARBINOLS ET COMPOSES CORRESPONDANTS
  申请人：SYNTHON BV

  公开号：WO2000026187A1

  公开（公告）日：2000-05-11

  Aryl-2-piperidones of formula (7) can be reduced to form aryl-piperidine carbinols of formula (1), which are useful in forming a variety of pharmaceutical compounds including paroxetine, in good yield and purity. Related compounds and synthesis schemes are also set forth. In said formulas, X represents a hydrogen atom, a halogen atom, a lower alkyl group, an aralkyl group, an alkoxy group, a dialkylamino group or an alkylthio group; R represents a hydrogen atom, a lower alkyl group, an aryl group, an aralkyl group, an alkoxycarbonyl group, aralkoxycarbonyl group or an aryloxycarbonyl group; and R1 represents a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group.