N-hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]sulfonylpiperidine-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]sulfonylpiperidine-4-carboxamide
• 化学式: C₂₁H₃₀F₃N₃O₇S
• 分子量: 525.5
• InChiKey: SMEDJCLQUBCAEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• Process for making alpha-substituted hydroxamic acids
  申请人：Babiak A. Kevin

  公开号：US20050043533A1

  公开（公告）日：2005-02-24

  This invention is directed generally to a process for making α-substituted hydroxamic acids (including salts thereof) generally corresponding in structure to Formula (I): wherein n, Z, Z 3 , A, R, E, and Y are as defined in this patent. This invention also is directed to compounds that may, for example, be used as intermediates in such a process, as well as processes for making such compounds.

  本发明通常涉及一种制备α-取代羟胺酸（包括其盐）的过程，其结构通常对应于公式（I）：其中n，Z，Z3，A，R，E和Y在本专利中定义。本发明还涉及化合物，例如可以用作这种过程中间体的化合物，以及制备这种化合物的过程。
• Sulfamato hydroxamic acid metalloprotease inhibitor
  申请人：Boehm L. Terri

  公开号：US20050049280A1

  公开（公告）日：2005-03-03

  A sulfamato hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a process for preparing the same, intermediate compounds useful in those syntheses, and a treatment process that comprises administering a contemplated sulfamato hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

  本发明公开了一种磺酰氨基羟肟酸化合物，该化合物在抑制基质金属蛋白酶活性方面具有作用，同时还公开了制备该化合物的方法，用于该合成的中间化合物以及治疗过程，该治疗过程包括向具有与病理基质金属蛋白酶活性相关的病情的宿主中以MMP酶抑制有效量的考虑中的磺酰氨基羟肟酸化合物的方式进行给药。
• SULFAMATO HYDROXAMIC ACID METALLOPROTEASE INHIBITOR
  申请人：G.D. SEARLE & CO.

  公开号：EP1157021A1

  公开（公告）日：2001-11-28
• US6492367B1
  申请人：——

  公开号：US6492367B1

  公开（公告）日：2002-12-10
• US6448250B1
  申请人：——

  公开号：US6448250B1

  公开（公告）日：2002-09-10