4-(p-nitrophenyl)-tetrahydro-4H-1,4-thiazine | 90254-22-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: 4-(p-nitrophenyl)-tetrahydro-4H-1,4-thiazine
• 英文别名: 4-(4-nitrophenyl)thiomorpholine；N-(4-nitrophenyl)thiomorpholine；4-(4-nitro-phenyl)-thiomorpholine
• CAS: 90254-22-1
• 化学式: C₁₀H₁₂N₂O₂S
• mdl: MFCD01604442
• 分子量: 224.283
• InChiKey: IRHIMRCEUXJBGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  74.4
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 4-(4-Nitrophenyl)thiomorpholine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 4-(4-Nitrophenyl)thiomorpholine
CAS number: 90254-22-1

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C10H12N2O2S
Molecular weight: 224.3

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-(p-nitrophenyl)-tetrahydro-4H-1,4-thiazine 在 platinum(IV) oxide sodium azide 、 水 、 氢气 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 20.0~65.0 ℃ 、196.12 kPa 条件下， 反应 22.0h， 生成 (S)-5-Aminomethyl-2-oxo-3-[4-(thiomorpholin-4-yl)phenyl]oxazolidine
  参考文献：
  名称：

  恶唑烷酮抗菌剂的构效关系（SAR）研究。2.在5-硫代羰基恶唑烷酮中亲脂性与抗菌活性之间的关系。

  摘要：

  考虑到分子的疏水性参数，对5-硫代羰基恶唑烷酮抗菌剂的研究继续进行，合成了5-硫脲和5-二硫代氨基甲酸酯恶唑烷酮。结构-活性关系（SAR）研究表明，亲脂性显着影响对5-硫代羰基恶唑烷酮的抗菌活性，尤其是计算出的log P值以及5-亲水（或疏水）取代基与疏水（或亲水）之间的平衡苯环上的取代基。发现一些5-硫代羰基恶唑烷酮对革兰氏阳性细菌具有良好的体外抗菌活性，包括耐甲氧西林的金黄色葡萄球菌（MRSA）和耐万古霉素的肠球菌（VRE）。

  DOI：

  10.1248/cpb.49.353
• 作为产物：
  描述：

  硫代吗啉 、 对氟硝基苯 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 17.0h， 生成 4-(p-nitrophenyl)-tetrahydro-4H-1,4-thiazine
  参考文献：
  名称：

  恶唑烷酮抗菌剂的构效关系（SAR）研究。2.在5-硫代羰基恶唑烷酮中亲脂性与抗菌活性之间的关系。

  摘要：

  考虑到分子的疏水性参数，对5-硫代羰基恶唑烷酮抗菌剂的研究继续进行，合成了5-硫脲和5-二硫代氨基甲酸酯恶唑烷酮。结构-活性关系（SAR）研究表明，亲脂性显着影响对5-硫代羰基恶唑烷酮的抗菌活性，尤其是计算出的log P值以及5-亲水（或疏水）取代基与疏水（或亲水）之间的平衡苯环上的取代基。发现一些5-硫代羰基恶唑烷酮对革兰氏阳性细菌具有良好的体外抗菌活性，包括耐甲氧西林的金黄色葡萄球菌（MRSA）和耐万古霉素的肠球菌（VRE）。

  DOI：

  10.1248/cpb.49.353

文献信息

• Therapeutic heterocyclic compounds
  申请人：——

  公开号：US20030013708A1

  公开（公告）日：2003-01-16

  Provided herein is a compound having the formula (I): 1 Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT 1B and 5HT 1D antagonists.

  本文提供的化合物具有以下式（I）： 其中所述化合物可用于治疗精神障碍，包括但不限于抑郁症、广泛性焦虑、进食障碍、痴呆症、恐慌障碍和睡眠障碍。这些化合物还可能用于治疗胃肠道障碍、心血管调节、运动障碍、内分泌障碍、血管痉挛和性功能障碍。这些化合物是5HT 1B和5HT 1D拮抗剂。
• Therapeutic chromone compounds
  申请人：——

  公开号：US20040087575A1

  公开（公告）日：2004-05-06

  Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT 1B antagonists. Also provided herein are processes for making compounds of Formula (I) and intermediate compounds.

  本文提供的是一种化合物，其化学式为（I），其中该化合物可用于治疗包括但不限于抑郁症、广泛性焦虑、进食障碍、痴呆症、恐慌障碍和睡眠障碍在内的精神疾病。这些化合物也可能对治疗胃肠道疾病、心血管调节、运动障碍、内分泌失调、血管痉挛和性功能障碍有用。这些化合物是5HT 1B 拮抗剂。本文还提供了制备化合物（I）和中间体化合物的方法。
• Therapeutic chroman compounds
  申请人：——

  公开号：US20040110745A1

  公开（公告）日：2004-06-10

  Provided herein is a compound represented by the Formula (I) wherein said compounds are useful for the treatment of migraine. Also provided are processes for the preparation of compounds of Formula (I) and intermediates.

  本文提供的是一种化合物，其化学式表示为（I），其中这些化合物对治疗偏头痛有用。还提供了制备化合物（I）和中间体的方法。
• Dipole moments of some N-phenyl-substituted derivatives of pyrrolidine, piperidine, morpholine, and thiomorpholine
  作者：Steven F. Beach、John D. Hepworth、John Sawyer、Geoffrey Hallas、Richard Marsden、Meta M. Mitchell、Douglas A. Ibbitson、Alan M. Jones、Graham T. Neal

  DOI：10.1039/p29840000217

  日期：——

  Apparent dipole moments in benzene of various p-substituted N-phenyl derivatives of pyrrolidine, piperidine, morpholine, and thiomorpholine and of some analogous NN-diethylanilines have been determined.

  已经确定了吡咯烷，哌啶，吗啉和硫代吗啉的各种对位取代的N-苯基衍生物以及一些类似的NN-二乙基苯胺在苯中的表观偶极矩。
• TRICYCLIC INHIBITORS OF KINASES
  申请人：Tong Yunsong

  公开号：US20120220572A1

  公开（公告）日：2012-08-30

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X, Y, Z, R 3 and R 4 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

  本发明涉及式(I)的化合物或药用可接受的盐，其中X、Y、Z、R3和R4在描述中有定义。本发明还涉及含有上述化合物的组合物，用于抑制wee-1等激酶，并治疗癌症等疾病的方法。