2,6-dimethyl piperidine-N-carboxamide | 97226-78-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2,6-dimethyl piperidine-N-carboxamide
• 英文别名: 2,6-Dimethylpiperidine-1-carboxamide
• CAS: 97226-78-3
• 化学式: C₈H₁₆N₂O
• 分子量: 156.228
• InChiKey: DEOJRJKNSVFSLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-dimethyl piperidine-N-carboxamide 以88%的产率得到
  参考文献：
  名称：

  SIDDIQUI, SALIMUZZAMAN;HAIDER, S. IMTIAZ;AHMAD, S. SALMAN;SIDDIQUI, B. SH+, Z. NATURFORSCH., 1985, 40, N 4, 546-549

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二甲基哌啶 在 盐酸 作用下， 生成 2,6-dimethyl piperidine-N-carboxamide
  参考文献：
  名称：

  Siddiqui, Salimuzzaman; Haider, S. Imtiaz; Ahmad, S. Salman, Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1985, vol. 40, # 4, p. 546 - 549

  摘要：

  DOI：

文献信息

• 6- (Heterocyclyl-substituted Benzyl) -4-Oxoquinoline Compound and Use Thereof as HIV Integrase Inhibitor
  申请人：SATOH Motohide

  公开号：US20080207618A1

  公开（公告）日：2008-08-28

  The present invention relates to a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical composition, an anti-HIV agent and an HIV integrase inhibitor containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an anti-HIV agent, or as an agent for the prophylaxis or treatment of AIDS. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Because it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.

  本发明涉及以下式[I]所表示的化合物，其中每个符号如规范中所定义，或其药学上可接受的盐，或其溶剂合物，以及含有此类化合物的药物组合物，抗HIV药物和HIV整合酶抑制剂。本发明的化合物具有HIV整合酶抑制活性，并可用作抗HIV药物，或用作艾滋病的预防或治疗药物。此外，通过与其他抗HIV药物（如蛋白酶抑制剂、逆转录酶抑制剂等）的联合使用，可以使其成为更有效的抗HIV药物。由于它显示出整合酶特异性的高抑制活性，该化合物可以成为对人体安全的药物，仅引起较少的副作用。
• Carbonyl substituted pyrazoline compounds, their preparation and use as CB1 receptor modulators
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1743888A1

  公开（公告）日：2007-01-17

  The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

  本发明涉及取代吡唑啉化合物，其制备方法，包含这些化合物的药物以及它们用于制备用于治疗人类和动物的药物的用途。
• Tetrahydrothiopyrano pyrazole cannabinoid modulators
  申请人：Liotta Fina

  公开号：US20060223798A1

  公开（公告）日：2006-10-05

  The invention relates to a CB modulator compound of Formula (I) or a pharmaceutically acceptable form thereof and a method for use in treating, ameliorating or preventing a CB receptor mediated syndrome, disorder or disease.

  该发明涉及一种化合物，其化学式为（I）或其药用可接受形式，以及用于治疗、改善或预防CB受体介导的综合征、疾病或疾病的方法。
• Substituted pyrazoline for preventing weight gain
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1946777A1

  公开（公告）日：2008-07-23

  The present invention relates to an active substance combination comprising at least one substituted pyrazoline compound and at least one drug, known to produce weight-gain as a side effect, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种活性物质组合，包括至少一种取代吡唑啉化合物和至少一种药物，该药物以体重增加作为副作用而知名，包括所述活性物质组合的药物、包括所述活性物质组合的药物制剂、以及利用所述活性物质组合制造药物。
• Pharmaceutical use of substituted amides
  申请人：Andersen Sune Henrik

  公开号：US20060111366A1

  公开（公告）日：2006-05-25

  The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

  本文介绍了使用取代酰胺来调节11β-羟化甾体脱氢酶1型（11βHSD1）的活性以及将这些化合物用作制药组合物的方法。还介绍了一类新型的取代酰胺，它们在治疗中的应用、包含这些化合物的制药组合物以及它们在药物制剂制造中的应用。这些化合物是11βHSD1的调节剂，更具体地说是抑制剂，可用于治疗、预防和/或预防一系列需要降低活性糖皮质激素细胞内浓度的医学疾病。