1-(3-hydroxy-3-methyl-1-butynyl)-4-(3-(triisopropoxysilyl)propyl)benzene | 1442416-75-2

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1-(3-hydroxy-3-methyl-1-butynyl)-4-(3-(triisopropoxysilyl)propyl)benzene
• 英文别名: 2-Methyl-4-[4-[3-tri(propan-2-yloxy)silylpropyl]phenyl]but-3-yn-2-ol；2-methyl-4-[4-[3-tri(propan-2-yloxy)silylpropyl]phenyl]but-3-yn-2-ol
• CAS: 1442416-75-2
• 化学式: C₂₃H₃₈O₄Si
• 分子量: 406.638
• InChiKey: YSQQIGUVMJVEJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.96
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(3-hydroxy-3-methyl-1-butynyl)-4-(3-(triisopropoxysilyl)propyl)benzene 在 sodium hydride 作用下， 以 甲苯 、 paraffin oil 为溶剂， 反应 1.08h， 以71%的产率得到1-ethynyl-4-(3-(triisopropoxysilyl)propyl)benzene
  参考文献：
  名称：

  A new synthetic approach for functional triisopropoxyorganosilanes using molecular building blocks

  摘要：

  We report an efficient synthetic approach for well-designed organic-bridged alkoxysilanes, which allow the formation of highly functional organosilica hybrids under mild sol gel conditions. A series of molecular building blocks containing a triisopropoxysilyl group were synthesized and used in cross-coupling reactions. The triisopropoxysilyl group showed a good tolerance for various organic transformations. 1,4-Diketo-3,6-dithienylpyrrolo[3,4-c]pyrrole-bridged triisopropoxysilane was successfully prepared, allowing rapid formation of organosilica hybrid without loss of functionality under mildly acidic conditions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.04.130
• 作为产物：
  描述：

  1,4-二溴苯 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 正丁基锂 、 Zeise's dimer 、 三氯硅烷 、 异丙基氯化镁 、 三乙胺 作用下， 以 四氢呋喃 、 吡啶 、 正己烷 、 二氯甲烷 为溶剂， 反应 64.75h， 生成 1-(3-hydroxy-3-methyl-1-butynyl)-4-(3-(triisopropoxysilyl)propyl)benzene
  参考文献：
  名称：

  A new synthetic approach for functional triisopropoxyorganosilanes using molecular building blocks

  摘要：

  We report an efficient synthetic approach for well-designed organic-bridged alkoxysilanes, which allow the formation of highly functional organosilica hybrids under mild sol gel conditions. A series of molecular building blocks containing a triisopropoxysilyl group were synthesized and used in cross-coupling reactions. The triisopropoxysilyl group showed a good tolerance for various organic transformations. 1,4-Diketo-3,6-dithienylpyrrolo[3,4-c]pyrrole-bridged triisopropoxysilane was successfully prepared, allowing rapid formation of organosilica hybrid without loss of functionality under mildly acidic conditions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.04.130

文献信息

• A new synthetic approach for functional triisopropoxyorganosilanes using molecular building blocks
  作者：Yoshifumi Maegawa、Minoru Waki、Akinari Umemoto、Toyoshi Shimada、Shinji Inagaki

  DOI：10.1016/j.tet.2013.04.130

  日期：2013.7

  We report an efficient synthetic approach for well-designed organic-bridged alkoxysilanes, which allow the formation of highly functional organosilica hybrids under mild sol gel conditions. A series of molecular building blocks containing a triisopropoxysilyl group were synthesized and used in cross-coupling reactions. The triisopropoxysilyl group showed a good tolerance for various organic transformations. 1,4-Diketo-3,6-dithienylpyrrolo[3,4-c]pyrrole-bridged triisopropoxysilane was successfully prepared, allowing rapid formation of organosilica hybrid without loss of functionality under mildly acidic conditions. (C) 2013 Elsevier Ltd. All rights reserved.