1-(5-Chloro-2,4-dinitrophenyl)-3-methyl-3-azabicyclo[3.1.0]hexane | 923567-70-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(5-Chloro-2,4-dinitrophenyl)-3-methyl-3-azabicyclo[3.1.0]hexane
• CAS: 923567-70-8
• 化学式: C12H12ClN3O4
• 分子量: 297.69
• InChiKey: PSKXRGIHPZVWJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  94.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Methods and compositions for the treatment of neuropathies and related disorders
  申请人：Lippa S. Arnold

  公开号：US20070082939A1

  公开（公告）日：2007-04-12

  The present invention provides novel compositions and methods for treating symptoms associated with neuropathic disorders such as hyperalgesia, allodynia, and parasthesias, using a 1-aryl-3-azabicyclo[3.1.0] hexane. The invention further relates to the use of 1-aryl-3-azabicyclo[3.1.0] hexanes in pharmaceutical compositions and methods for treating neuropathic disorders and related symptoms in mammals. Patients amenable to treatment according to the invention include those suffering from diabetic neuropathies, post-herpetic neuralgia, trigeminal neuralgia, chronic lower back pain, sciatica, idiopathic and post-traumatic neuropathies, HIV-associated neuropathic pain, among many other neuropathic disorders and related symptoms.

  本发明提供了一种新型组合物和方法，用于治疗与神经病理性疾病相关的症状，如过度疼痛、触痛和感觉异常，使用1-芳基-3-氮杂双环[3.1.0]己烷。本发明还涉及在制药组合物中使用1-芳基-3-氮杂双环[3.1.0]己烷以及治疗哺乳动物神经病理性疾病和相关症状的方法。根据本发明可治疗的患者包括患有糖尿病神经病变、带状疱疹后遗神经痛、三叉神经痛、慢性腰痛、坐骨神经痛、特发性和创伤后神经病变、HIV相关神经病理性疼痛等许多神经病理性疾病和相关症状的患者。
• Novel 1-Aryl-3-Azabicyclo[3.1.0]Hexanes: Preparation And Use To Treat Neuropsychiatric Disorders
  申请人：NEUROVANCE, INC.

  公开号：US20150148399A1

  公开（公告）日：2015-05-28

  The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.

  本发明提供了新型的多取代的1-芳基-3-氮杂双环[3.1.0]己烷，以及制备这些化合物的相关过程和中间体，以及使用这些化合物进行治疗和/或预防中枢神经系统（CNS）疾病，包括抑郁症和焦虑症的组合物和方法。
• 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
  申请人：OTSUKA AMERICA PHARMACEUTICAL, INC.

  公开号：US10039746B2

  公开（公告）日：2018-08-07

  The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.

  本发明提供了新型的多取代1-芳基-3-氮杂双环[3.1.0]己烷、制备这些化合物的相关工艺和中间体，以及使用这些化合物治疗和/或预防中枢神经系统（CNS）疾病（包括抑郁症和焦虑症）的组合物和方法。
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPATHIES AND RELATED DISORDERS
  申请人：DOV Pharmaceutical, Inc.

  公开号：EP1915148A2

  公开（公告）日：2008-04-30
• US8461196B2
  申请人：——

  公开号：US8461196B2

  公开（公告）日：2013-06-11